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Titolo:
PSYCHIATRIC DIAGNOSES IN THE CHILD AND ADOLESCENT MEMBERS OF EXTENDEDFAMILIES IDENTIFIED THROUGH ADULT BIPOLAR AFFECTIVE-DISORDER PROBANDS
Autore:
TODD RD; REICH W; PETTI TA; JOSHI P; DEPAULO JR; NURNBERGER J; REICH T;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,BOX 8134,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 INDIANA UNIV,SCH MED,DEPT PSYCHIAT INDIANAPOLIS IN 46202 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT BALTIMORE MD 21205
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 5, volume: 35, anno: 1996,
pagine: 664 - 671
SICI:
0890-8567(1996)35:5<664:PDITCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOPATHOLOGY; ILLNESS; SEGREGATION; RELATIVES; PARENTS;
Keywords:
CHILDREN; BIPOLAR DISORDER; MAJOR DEPRESSIVE DISORDER; FAMILY STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Todd et al., "PSYCHIATRIC DIAGNOSES IN THE CHILD AND ADOLESCENT MEMBERS OF EXTENDEDFAMILIES IDENTIFIED THROUGH ADULT BIPOLAR AFFECTIVE-DISORDER PROBANDS", Journal of the American Academy of Child and Adolescent Psychiatry, 35(5), 1996, pp. 664-671

Abstract

Objective: To investigate the type and distribution of psychiatric disorders in the child and adolescent members of extended pedigrees identified through bipolar probands. Method: The child and adolescent offspring (24 male, 26 female, aged 6 to 17 years) and the adult parents (60) of 14 bipolar pedigrees ascertained for the National Institutes ofMental Health Genetics Initiative Study of Bipolar Affective Disorderwere personally assessed using structured psychiatric interviews. A parent was also interviewed about each child or adolescent offspring. Results: Twelve of the 50 interviewed offspring received a lifetime DSM-III-R diagnosis of an affective disorder. This included six cases of bipolar disorder, five cases of major depressive disorder, and one case of dysthymia. Eight of the offspring who received an affective disorder diagnosis also qualified for an anxiety disorder (four), a disruptive behavior disorder (two), or both (two). Offspring who had a parentwith an affective disorder had a 5.1-fold higher risk for receiving an affective disorder diagnosis than did offspring with healthy parents. Conclusions: In a consecutive series of families identified through a proband with bipolar disorder, there were significant increases in the prevalence of affective disorder diagnoses in the child and adolescent offspring. The distribution of illness in offspring was compatiblewith the presence of important genetic factors which contribute to early-onset affective illness.

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Documento generato il 12/07/20 alle ore 06:55:39