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Titolo:
ABNORMALLY PHOSPHORYLATED TAU-PROTEIN IN SENILE DEMENTIA OF LEWY BODYTYPE AND ALZHEIMER-DISEASE - EVIDENCE THAT THE DISORDERS ARE DISTINCT
Autore:
STRONG C; ANDERTON BH; PERRY RH; PERRY EK; INCE PG; LOVESTONE S;
Indirizzi:
INST PSYCHIAT,DEPT NEUROSCI,NEURODEGENERAT DIS RES GRP,DE CRESPIGNY PK LONDON SE5 8AF ENGLAND INST PSYCHIAT,DEPT NEUROSCI,NEURODEGENERAT DIS RES GRP LONDON SE5 8AFENGLAND NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Alzheimer disease and associated disorders
fascicolo: 4, volume: 9, anno: 1995,
pagine: 218 - 222
SICI:
0893-0341(1995)9:4<218:APTISD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; NEUROFIBRILLARY TANGLES; CLINICAL-FEATURES; BODIES; EPITOPES; NEUROFILAMENT;
Keywords:
LEWY BODY; DEMENTIA; TAU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Strong et al., "ABNORMALLY PHOSPHORYLATED TAU-PROTEIN IN SENILE DEMENTIA OF LEWY BODYTYPE AND ALZHEIMER-DISEASE - EVIDENCE THAT THE DISORDERS ARE DISTINCT", Alzheimer disease and associated disorders, 9(4), 1995, pp. 218-222

Abstract

The relationship between Alzheimer disease (AD) and dementia with Lewy bodies (senile dementia Lewy body type, or SDLT) and dementia in Parkinson's disease is unclear. AD pathology is characterised by both amyloid deposition and abnormal phosphorylation of tau in paired helical filaments (PHF-tau). In AD, abnormally phosphorylated PHF-tau is present in neurofibrillary tangles, in neuritic processes of senile plaques, and also in neuropil threads dispersed throughout the cerebral cortex. Cortical homogenates from 12 cases each of AD and SDLT, 13 cases ofParkinson's disease, and 11 normal controls were examined by Western blot analysis with antibodies that detect PHF-tau. No PHF-tau was found in Parkinson's disease or control cortex. No PHF-tau was found in SDLT cases without histological evidence of tangles. PHF-tau was detectable in SDLT cases with a low density of tangles, and large amounts of PHF-tau were present in AD cases. This study demonstrates that abnormally phosphorylated PHF-tau is only present where tangles are found andnot in SDLT cases without tangles or with only occasional tangles. Itis concluded that Lewy body dementias are distinct at a molecular level from AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:47:58