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Titolo:
THYMIC EPITHELIAL TUMORS - EVALUATION OF MALIGNANT GRADE BY QUANTIFICATION OF PROLIFERATING CELL NUCLEAR ANTIGEN AND NUCLEOLAR ORGANIZER REGIONS
Autore:
TATEYAMA H; MIZUNO T; TADA T; EIMOTO T; HASHIMOTO T; MASAOKA A;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PATHOL,KAWASUMI 1,MIZUHO KU NAGOYA AICHI 467 JAPAN NAGOYA CITY UNIV NAGOYA AICHI 467 JAPAN
Titolo Testata:
Virchows Archiv. A. Pathological anatomy and histology
fascicolo: 4, volume: 422, anno: 1993,
pagine: 265 - 269
SICI:
0174-7398(1993)422:4<265:TET-EO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CARCINOMA; PCNA; THYMOMAS; PROTEIN; COUNTS;
Keywords:
THYMUS; THYMOMA; THYMIC CARCINOMA; PROLIFERATING CELL NUCLEAR ANTIGEN; NUCLEOLAR ORGANIZER REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
H. Tateyama et al., "THYMIC EPITHELIAL TUMORS - EVALUATION OF MALIGNANT GRADE BY QUANTIFICATION OF PROLIFERATING CELL NUCLEAR ANTIGEN AND NUCLEOLAR ORGANIZER REGIONS", Virchows Archiv. A. Pathological anatomy and histology, 422(4), 1993, pp. 265-269

Abstract

Cellular proliferation was studied by quantification of proliferatingcell nuclear antigen (PCNA) and argyrophilic nucleolar organizer regions (AgNORs) of cells in 29 thymic epithelial tumours: 8 noninvasive (7 cortical and 1 mixed) thymomas, 11 invasive/metastatic (all cortical) thymomas, and 10 thymic carcinomas. Thymic carcinoma showed the highest percentage of cells positive for PCNA (14.73 +/- 5.419%) and the largest mean number of AgNORs per nucleus (4.89 +/- 0.756). The mean percentage of PCNA-positive cells and number of AgNORs in thymoma groupswere as follows: in noninvasive thymoma 2.96 +/- 1.256% and 2.73 +/- 0.647, respectively, and in invasive/metastatic thymoma 4.41 +/- 1.823% and 3.68 +/- 1.148, respectively. The differences in PCNA and AgNORswere statistically significant between thymic carcinoma and each of thymoma groups. The overlap of the values between these tumours was minimal in the PCNA stains, although it was considerable in AgNOR counts as previously noted. However, there was no statistically significant difference in these markers between noninvasive and invasive/metastaticthymomas. These results indicate that thymoma in general is a slow-growing tumour compared with thymic carcinoma and that noninvasive thymoma is similar to invasive/metastatic thymoma with regard to proliferative activity; these latter two tumours may represent an essentially identical type in different stages of progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:07:43