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Titolo:
CONTRAST ENHANCEMENT IN EXPERIMENTAL RADIATION-INDUCED LIVER-INJURY -COMPARISON OF HEPATOCELLULAR AND RETICULOENDOTHELIAL PARTICULATE CONTRAST AGENTS
Autore:
STISKAL M; SCHWICKERT HC; DEMSAR F; ROBERTS TPL; SZOLAR D; WEISSLEDER R; BRASCH RC;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT RADIOL,CONTRAST MEDIA LAB SAN FRANCISCOCA 94143 UNIV CALIF SAN FRANCISCO,DEPT RADIOL,CONTRAST MEDIA LAB SAN FRANCISCOCA 94143
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 2, volume: 6, anno: 1996,
pagine: 286 - 290
SICI:
1053-1807(1996)6:2<286:CEIERL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; PRECLINICAL EVALUATION; MR; HEPATITIS;
Keywords:
CONTRAST MEDIA; EXPERIMENTAL MODEL; IRON PARTICLES; RADIATION HEPATITIS; MAGNETIC RESONANCE (MR) IMAGING; ECHO-PLANAR IMAGING [EPI]; LIVER CONTRAST ENHANCEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Stiskal et al., "CONTRAST ENHANCEMENT IN EXPERIMENTAL RADIATION-INDUCED LIVER-INJURY -COMPARISON OF HEPATOCELLULAR AND RETICULOENDOTHELIAL PARTICULATE CONTRAST AGENTS", Journal of magnetic resonance imaging, 6(2), 1996, pp. 286-290

Abstract

We compared the liver enhancement of two superparamagnetic agents, polycrystalline iron oxide nanoparticles (PION) and PION coated with asialofetuin (ASF), in an experimental model of focal radiation-induced hepatitis. PION, a reticuloendothelial system-directed agent, and PION;ASF, a hepatocellular-directed agent, were compared for time-dependentliver enhancement in an experimental model of radiation-induced liverinjury. Using the reticuloendothelial system (RES)-directed PION, thenormal, nonirradiated portion of the liver decreased in signal intensity (SI) with a mean negative enhancement of -66% +/-4, whereas the irradiated portion (60 Gy, 3 days before imaging) of the liver decreasedin SI by -24% +/-2, significantly less (P < .05). SI changes in irradiated liver tissue using PION were dose-dependent, being more pronounced with lower radiation exposure. The difference in SI changes inducedby PION-ASF between irradiated and nonirradiated liver was not statistically different, but SI decreased with a mean negative enhancement of -80% +/-2. The RES-directed PION is more sensitive for the detectionof radiation-induced hepatitis than is the hepatocyte-directed PION-ASF. The insensitivity of PION-ASF enhancement for diffuse liver injurymay be clinically advantageous for detecting focal lesions in the presence of diffuse hepatic injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:44:03