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Titolo:
POSTSYNAPTIC ELEVATION OF CALCIUM INDUCES PERSISTENT DEPRESSION OF DEVELOPING NEUROMUSCULAR SYNAPSES
Autore:
CASH S; DAN Y; POO MM; ZUCKER R;
Indirizzi:
COLUMBIA UNIV,DEPT BIOL SCI NEW YORK NY 10027 UNIV CALIF BERKELEY,DIV NEUROBIOL BERKELEY CA 94720
Titolo Testata:
Neuron
fascicolo: 4, volume: 16, anno: 1996,
pagine: 745 - 754
SICI:
0896-6273(1996)16:4<745:PEOCIP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NERVE-MUSCLE INTERACTIONS; XENOPUS CELL-CULTURE; SYNAPTIC TRANSMISSION; PROTEIN-KINASE; NITRIC-OXIDE; SKELETAL-MUSCLE; AREA CA1; HIPPOCAMPUS; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
S. Cash et al., "POSTSYNAPTIC ELEVATION OF CALCIUM INDUCES PERSISTENT DEPRESSION OF DEVELOPING NEUROMUSCULAR SYNAPSES", Neuron, 16(4), 1996, pp. 745-754

Abstract

Synaptic activity is known to modulate neuronal connectivity in the nervous system. At developing Xenopus neuromuscular synapses in culture, repetitive postsynaptic application of ACh near the synapse leads toimmediate and persistent synaptic depression, which was shown to be caused by reduction of presyaptic evoked transmitter release. However, little depression was found when ACh was applied to the muscle 20 mu mor further from the synapse. Fluorescence imaging of cytosolic Ca2+ ([Ca2+](i)) showed that each ACh pulse induced a transient elevation ofmyocyte [Ca2+], that spread approximately 20 mu m. Local photoactivated release of Ca2+ from the caged Ca2+ chelators nitr-5 or nitrophen in the postsynaptic cell was sufficient to induce persistent synaptic depression. These results support a model in which localized Ca2+ influx into the postsynaptic myocyte initiates transsynaptic retrograde modulation of presynaptic secretion mechanisms.

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Documento generato il 05/04/20 alle ore 03:51:50