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Titolo:
NOVEL 1,2,4-OXADIAZOLES AS POTENT AND SELECTIVE HISTAMINE H-3 RECEPTOR ANTAGONISTS
Autore:
CLITHEROW JW; BESWICK P; IRVING WJ; SCOPES DIC; BARNES JC; CLAPHAM J; BROWN JD; EVANS DJ; HAYES AG;
Indirizzi:
GLAXO WELLCOME MED RES CTR,DEPT MED CHEM STEVENAGE SG1 2NY HERTS ENGLAND GLAXO WELLCOME MED RES CTR,DEPT PHARMACOL STEVENAGE SG1 2NY HERTS ENGLAND
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 7, volume: 6, anno: 1996,
pagine: 833 - 838
SICI:
0960-894X(1996)6:7<833:N1APAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Clitherow et al., "NOVEL 1,2,4-OXADIAZOLES AS POTENT AND SELECTIVE HISTAMINE H-3 RECEPTOR ANTAGONISTS", Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 833-838

Abstract

Replacement of the isothiourea moiety of known histamine H-3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H-3 antagonist. Copyright (C) 1996 Elsevier Science Ltd

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:13:32