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Titolo:
BASIC FIBROBLAST GROWTH-FACTOR WITHIN ENDOTHELIAL-CELLS DURING VASCULARIZATION OF THE ANTERIOR-PITUITARY
Autore:
SCHECHTER J; PATTISON A; PATTISON T;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT CELL & NEUROBIOL,1333 SAN PABLO ST LOS ANGELES CA 90033
Titolo Testata:
The Anatomical record
fascicolo: 1, volume: 245, anno: 1996,
pagine: 46 - 52
SICI:
0003-276X(1996)245:1<46:BFGWED>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; EXTRACELLULAR-MATRIX; ANGIOGENIC PROTEIN; DNA-SYNTHESIS; MEMBRANE; RAT; STIMULATION; VASCULATURE; FISCHER-344; TISSUES;
Keywords:
FIBROBLAST GROWTH FACTOR; ANTERIOR PITUITARY; ENDOTHELIUM; VASCULARIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J. Schechter et al., "BASIC FIBROBLAST GROWTH-FACTOR WITHIN ENDOTHELIAL-CELLS DURING VASCULARIZATION OF THE ANTERIOR-PITUITARY", The Anatomical record, 245(1), 1996, pp. 46-52

Abstract

Background: Basic fibroblast growth factor (FGF-2), a potent angiogenic peptide, is known to be present in gonadotropes of the anterior pituitary parenchyma of rats and mice, and has been isolated from endothelial cells of many organs. Its localization within endothelial cells has not been determined, nor the mechanisms by which it might be released from endothelial cells during normal organogenesis. Methods: Localization of FGF within endothelial cells of the anterior pituitary was accomplished by immunocytochemistry and studied by light- and electron microscopy. Capillaries within the anterior pituitary were studied in fetal rats from day 15 to term, and in adult rats. Results: At the onset stages of vascularization (15-18 days fetal), the cytoplasm of the endothelial cells of many of the invading, immature capillaries (thick-walled with few or no fenestrations) was intensely immunopositive forFGF. Immunoprecipitate-filled blebs and slender cytoplasmic processesprojected from the endothelial cells into the presumptive pericapillary space and toward the parenchymal cells. As gestation progressed (19-20 day fetal), and an increasing number of capillaries acquired the features characteristic of capillaries in the anterior pituitary of adult animals, i.e., thin-walled and fenestrated, there were fewer capillaries demonstrating immunopositivity for FGF. Foci of released FGF, i.e., extracellular, were occasionally evident within the presumptive pericapillary spaces throughout gestation. By comparison, capillaries ofthe anterior pituitary of adult rats did not contain immunostainable FGF in their cytoplasm, nor were any blebs and/or processes filled with immunoprecipitate evident. However capillaries did reveal an immunopositive enhancement of their lumenal and ablumenal surfaces. Conclusions: During vascularization of the anterior pituitary, FGF within the cytoplasm of endothelial cells is released from blebs and/or processes of endothelial cells, and after the capillary bed is stabilized postnatally, these characteristics of vascularization are absent. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:00:45