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Titolo:
PREDOMINANCE OF AORTIC CALCIFICATION AS AN ATHEROSCLEROTIC MANIFESTATION IN WOMEN - THE REYKJAVIK STUDY
Autore:
DANIELSEN R; SIGVALDASON H; THORGEIRSSON G; SIGFUSSON N;
Indirizzi:
UNIV HOSP,LANDSPITALINN,DEPT MED IS-101 REYKJAVIK ICELAND HEART PREVENT CLIN REYKJAVIK ICELAND
Titolo Testata:
Journal of clinical epidemiology
fascicolo: 3, volume: 49, anno: 1996,
pagine: 383 - 387
SICI:
0895-4356(1996)49:3<383:POACAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-DISEASE; RISK;
Keywords:
AORTIC CALCIFICATION; PREVALENCE; ATHEROSCLEROTIC RISK FACTORS; CORONARY HEART DISEASE; PERIPHERAL ARTERY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R. Danielsen et al., "PREDOMINANCE OF AORTIC CALCIFICATION AS AN ATHEROSCLEROTIC MANIFESTATION IN WOMEN - THE REYKJAVIK STUDY", Journal of clinical epidemiology, 49(3), 1996, pp. 383-387

Abstract

Since 1967 the Reykjavik study has monitored coronary artery disease and its risk factors in randomly selected cohorts. From 1979 to 1984, 3246 men and 3545 women aged 45-74 years were studied. Routine biplanechest X rays were assessed by a radiologist who noted the presence orabsence of aortic calcification (AC), but had no detailed knowledge of the subjects. Overall, AC was diagnosed in 283 (8%) women, but in only 54 of the men (1.7%). In the women, the prevalence of AC increased from 2.0% at age 45-49 years to 17.1% at the age of 70-74 years, whilein men it was 0 and 8.3%, respectively. In women, multivariate analysis of risk factors showed AC to be positively related to systolic and negatively related to diastolic blood pressure, indicating a potentialrelation to pulse pressure. Furthermore, AC was independently associated with age, drug treatment for hypertension, nonfasting blood sugar,use of antidiabetic drugs, total serum cholesterol levels, and the amount of smoking. Too few men had AC for multivariate assessment of risk factors. In addition, in women AC was also related to a previous myocardial infarction (P < 0.05), mortality from coronary artery disease (p < 0.01), and the presence of intermittent claudication (P < 0.01). In men, however, AC was related only to total mortality (p < 0.05). Thus, these data show AC to be more prevalent in women, independently associated with recognized atherosclerotic risk factors, and a potentialmarker for coronary and peripheral artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:20:19