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Titolo:
EXPRESSION OF FOS PROTEIN IN VARIOUS RAT-BRAIN AREAS FOLLOWING ACUTE NICOTINE AND DIAZEPAM
Autore:
SALMINEN O; LAHTINEN S; AHTEE L;
Indirizzi:
UNIV HELSINKI,DEPT PHARM,DIV PHARMACOL & TOXICOL,POB 56,VIIKINKAARI 5SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT PHARM,DIV PHARMACOL & TOXICOL SF-00014 HELSINKI FINLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 54, anno: 1996,
pagine: 241 - 248
SICI:
0091-3057(1996)54:1<241:EOFPIV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS; PARAVENTRICULAR NUCLEUS; CHOLINERGIC SYSTEMS; MESSENGER-RNA; H-3 NICOTINE; INDUCTION; STIMULATION; INJECTIONS; NEURONS; STRESS;
Keywords:
NICOTINE; DIAZEPAM; C-FOS; IMMUNOHISTOCHEMISTRY; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
O. Salminen et al., "EXPRESSION OF FOS PROTEIN IN VARIOUS RAT-BRAIN AREAS FOLLOWING ACUTE NICOTINE AND DIAZEPAM", Pharmacology, biochemistry and behavior, 54(1), 1996, pp. 241-248

Abstract

We studied the effects of an acute dose of (-)-nicotine (1 mg/kg) on Fos-like immunostaining (IS) in rat brain areas. Nicotine increased Fos IS significantly in the medial terminal nucleus of accessory optic tract (MT), and tended to increase it in the interpeduncular nucleus (IP), as well as in the stress-related areas, the paraventricular hypothalamic nucleus (PVN) and the supraoptic nucleus (SON). Previously nicotine was reported to increase Fos IS also in another stress-related area, the central nucleus of amygdala (ACe). This led us to study the-interaction of nicotine with diazepam (10 mg/kg). Diazepam alone increased Fos IS in PVN and in SON as well as in ACe. In diazepam- and nicotine-treated rats Fos IS was increased in PVN and SON as well as in MT and IP. In MT and IP of diazepam and nicotine-treated rats Fos IS was similar to that induced by nicotine alone, and in PVN and SON of these rats Fos IS was similar to that induced by diazepam alone. Nicotine tended to antagonise the diazepam-induced elevation of Fos IS in ACe. Taken together, diazepam induced Fos IS in all stress-related areas studied (PVN, SON, ACe), but not in central visual structures, where nicotine induces Fos IS (MT, IP). No significant interactions on Fos expression were found between acute effects of diazepam and nicotine suggesting that these drugs activate different sets of neurons within the stress-related brain areas.

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Documento generato il 25/11/20 alle ore 07:37:45