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Titolo:
PSYCHOSOCIAL STRESS IN TREE SHREWS - CLOMIPRAMINE COUNTERACTS BEHAVIORAL AND ENDOCRINE CHANGES
Autore:
FUCHS E; KRAMER M; HERMES B; NETTER P; HIEMKE C;
Indirizzi:
GERMAN PRIMATE CTR,DIV NEUROBIOL,KELLNERWEG 4 D-37077 GOTTINGEN GERMANY UNIV GIESSEN,INST PSYCHOL W-6300 GIESSEN GERMANY UNIV MAINZ,DEPT PSYCHIAT W-6500 MAINZ GERMANY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 54, anno: 1996,
pagine: 219 - 228
SICI:
0091-3057(1996)54:1<219:PSITS->2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; TUPAIA-BELANGERI; GLUCOCORTICOID RECEPTOR; BLOOD-PRESSURE; HIPPOCAMPUS; DEPRESSION; RATS; CATECHOLAMINES; NOREPINEPHRINE; ANTIDEPRESSANT;
Keywords:
ANTIDEPRESSANT; CORTISOL; DEPRESSION; GROOMING; HPA AXIS; LOCOMOTOR ACTIVITY; MARKING BEHAVIOR; NOREPINEPHRINE; RISK ASSESSMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
E. Fuchs et al., "PSYCHOSOCIAL STRESS IN TREE SHREWS - CLOMIPRAMINE COUNTERACTS BEHAVIORAL AND ENDOCRINE CHANGES", Pharmacology, biochemistry and behavior, 54(1), 1996, pp. 219-228

Abstract

Male tree shrews (Tupaia belangeri) provide an animal model to study the neurobehavioral consequences of chronic psychosocial stress. When living in visual and olfactory contact with a male conspecific by which it has been defeated, the subordinate tree shrew shows dramatic behavioral, physiological, and neuroendocrine changes. Because the over all pattern of these changes resemble a depression-like symptomatology, we investigated to what extent the behavioral and endocrine changes insubordiante animals can be reversed by treatment with the tricyclic antidepressant clomipramine. In the present study, animals were subjected to a 10-day period of psychosocial conflict to elicit stress-induced behavioral and endocrine alterations before the onset of drug treatment, and psychosocial stress continued throughout the treatment periodof 30 days. Clomipramine was administered orally once daily at a doseof 50 mg/kg. The drug had a time-dependent restorative influence on marking and grooming behavior, locomotor activity, risk assessment, as well as on urinary cortisol and norepinephrine excretion. It, thus, appears that the clomipramine treatment counteracts the behavioral and endocrine effects of chronic psychosocial stress in tree shrews, and the time course of recovery corresponds closely to that observed when treating depressed patients in the clinic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:16:03