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Titolo:
SELECTIVE EFFECTS OF 8-OH-DPAT ON SOCIAL COMPETITION IN THE RAT
Autore:
WOODALL KL; DOMENEY AM; KELLY ME;
Indirizzi:
UNIV BRADFORD,SCH PHARM BRADFORD BD7 1DP W YORKSHIRE ENGLAND UNIV BRADFORD,SCH PHARM BRADFORD BD7 1DP W YORKSHIRE ENGLAND BATTELLE EUROPE,CTR RECH GENEVE CH-1227 CAROUGE GENEVE SWITZERLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 54, anno: 1996,
pagine: 169 - 173
SICI:
0091-3057(1996)54:1<169:SEO8OS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; MALE WISTAR RATS; NUCLEUS-ACCUMBENS; SUCROSE-PELLETS; 5-HT1A AGONIST; X-MAZE; BUSPIRONE; BEHAVIOR; ANXIETY; TRIADS;
Keywords:
ANXIETY; 8-OH-DPAT; SOCIAL COMPETITION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Woodall et al., "SELECTIVE EFFECTS OF 8-OH-DPAT ON SOCIAL COMPETITION IN THE RAT", Pharmacology, biochemistry and behavior, 54(1), 1996, pp. 169-173

Abstract

Previous research has demonstrated that dominant-subordinate relationships measured in small groups of rats competing for access to palatable food or fluids can be disrupted by both anxiolytic and anxiogenic drugs, and it has been proposed as a possible animal model of anxiety. The present study investigated the effects of the selective 5-HT1A agonist 8-OH-DPAT on the rank order of triads of rats measured in terms of access to sweetened milk. The effect of 8-OH-DPAT on locomotor activity and intake of sweetened milk was also determined. 8-OH-DPAT (25 and 37.5 mu g/kg) significantly increased the subordinate animals position in the social hierarchy without effect on the individual intakes ofsweetened milk or locomotor activity. The same doses administered to dominant animals had no effect on any of the parameters measured. The 8-OH-DPAT-induced increase in social competition in subordinate rats was dissociable from effects on feeding behavior and locomotor activity. The results from this study provide further evidence that social competition in groups of rats may represent a model that can be used to detect drugs acting via receptor mechanisms believed to be implicated in anxiety.

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Documento generato il 19/01/20 alle ore 06:04:03