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Titolo:
STRAIN DIFFERENCES IN FEAR-MOTIVATED BEHAVIOR OF RATS
Autore:
REX A; SONDERN U; VOIGT JP; FRANCK S; FINK H;
Indirizzi:
HUMBOLDT UNIV BERLIN,DEPT PHARMACOL & TOXICOL D-10098 BERLIN GERMANY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 54, anno: 1996,
pagine: 107 - 111
SICI:
0091-3057(1996)54:1<107:SDIFBO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-ANXIETY AGENTS; ELEVATED PLUS-MAZE; ANIMAL-MODELS; SOCIAL-INTERACTION; VALIDATION; DRUGS; TESTS;
Keywords:
ANXIETY; STRAIN DIFFERENCES; EXPLORATION; HOLEBOARD; CONFLICT TEST; SOCIAL INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Rex et al., "STRAIN DIFFERENCES IN FEAR-MOTIVATED BEHAVIOR OF RATS", Pharmacology, biochemistry and behavior, 54(1), 1996, pp. 107-111

Abstract

Studies have shown different and sometimes contradictory results in response to anxiolytic drugs. In the present study, the behaviorial performance of rat strains, obtained from different breeders, was examined in four animal models of anxiety- or in exploration-related behaviorto assess the potential contribution of genetic disposition or breeding factors to aversion-motivated behavior. Male rats: Wistar/Winkelmann, Wistar/Charles River, Wistar/BGVV, Lewis/Charles River, Fischer/Charles River, Brown Norway/Charles River were used in a conflict test inthe open field, a free exploratory paradigm, social interaction test,and the holeboard test. The results show that robust behaviorial differences in anxiety or exploration exist between different strains of rat and animals of one strain, obtained from different breeders. The differences shown in anxiety-related behavior might explain sometimes contradictory effects following the treatment with anxiolytic or anxiogenic drugs. The results indicate that genetic factors and breeding conditions substantially contribute to anxiety-motivated behaviors in animal models of anxiety. These differences in anxiety-related behavior may also be related to biochemical differences.

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Documento generato il 09/04/20 alle ore 00:15:31