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Titolo:
MODULATION OF PLUS-MAZE BEHAVIOR IN MICE BY THE PREFERENTIAL D-3-RECEPTOR AGONIST 7-OH-DPAT
Autore:
RODGERS RJ; JOHNSON NJT; CHAMPION AJ; MILLS S;
Indirizzi:
UNIV LEEDS,DEPT PSYCHOL,ETHOPHARMACOL LAB LEEDS LS2 9JT W YORKSHIRE ENGLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 54, anno: 1996,
pagine: 79 - 84
SICI:
0091-3057(1996)54:1<79:MOPBIM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE RECEPTOR AGONIST; DEFENSIVE BEHAVIOR; MOUSE; RAT; LOCALIZATION; SULPIRIDE; CATALEPSY; ANXIETY; SYSTEMS; STRESS;
Keywords:
ANXIETY; ELEVATED PLUS-MAZE; ETHOLOGY; RISK ASSESSMENT; DOPAMINE D-3 RECEPTORS; 7-OH-DPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Rodgers et al., "MODULATION OF PLUS-MAZE BEHAVIOR IN MICE BY THE PREFERENTIAL D-3-RECEPTOR AGONIST 7-OH-DPAT", Pharmacology, biochemistry and behavior, 54(1), 1996, pp. 79-84

Abstract

Differences in the behavioural profiles of dopamine D-2 receptor antagonists (e.g., haloperidol vs. sulpiride) in animal models of anxiety have prompted speculation concerning the importance of their relative affinities for D-2-like receptor populations. In an initial attempt toinvestigate the involvement of D-3 receptors in anxiety, the present study examined the effects of the preferential D-3-receptor agonist, (/-)7-OH-DPAT (0.01-10.0 mg/kg), on behaviours displayed by male mice in the elevated plus-maze paradigm. An ethological approach incorporating measurement of a range of defensive acts and postures in addition to conventional parameters was used to provide a comprehensive behavioural profile for the compound. Data analysis indicated a significant increase in percentage of open-arm entries at 10 mg/kg and an altered temporal distribution of behaviour at 1-10 mg/kg. Furthermore, risk-assessment measures (stretched attend postures, closed-arm returns) were dose dependently reduced by drug treatment. Although these behaviouralchanges would be consistent with anxiety reduction, such an interpretation is negated by dose-dependent decreases in all active behaviours (arm entries, rearing, and head-dipping) and by marked increases in entry latencies and nonexploratory behaviour at the highest dose tested. Overall, these effects are remarkably similar to those previously reported for quinpirole, suggesting either that D-2 and D-3 receptors exert similar behavioural control or that the agents employed are sufficiently potent at D-2 receptors to prevent a resolution of D-2 and D-3 responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:38:27