Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TREATMENT RESULTS, SURVIVAL AND PROGNOSTIC FACTORS IN 109 INFLAMMATORY BREAST CANCERS - UNIVARIATE AND MULTIVARIATE-ANALYSIS
Autore:
ATTIASOBOL J; FERRIERE JP; CURE H; KWIATKOWSKI F; ACHARD JL; VERRELLE P; FEILLEL V; DELATOUR M; LAFAYE C; DELOCHE C; DAUPLAT J; DOLY A; ROZAN R; CHOLLET P;
Indirizzi:
CTR JEAN PERRIN,RUE MONTALEMBERT,BP 392 F-63011 CLERMONT FERRAND FRANCE CTR JEAN PERRIN,RUE MONTALEMBERT,BP 392 F-63011 CLERMONT FERRAND FRANCE INSERM,U71 F-63011 CLERMONT FERRAND FRANCE
Titolo Testata:
European journal of cancer
fascicolo: 8, volume: 29A, anno: 1993,
pagine: 1081 - 1088
SICI:
0959-8049(1993)29A:8<1081:TRSAPF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMBINED MODALITY APPROACH; CARCINOMA; CHEMOTHERAPY; MANAGEMENT; SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J. Attiasobol et al., "TREATMENT RESULTS, SURVIVAL AND PROGNOSTIC FACTORS IN 109 INFLAMMATORY BREAST CANCERS - UNIVARIATE AND MULTIVARIATE-ANALYSIS", European journal of cancer, 29A(8), 1993, pp. 1081-1088

Abstract

Between 1978 and 1987, 109 patients without metastatic disease were treated by induction chemotherapy for inflammatory breast cancer (IBC) or ''neglected'' locally advanced breast cancer (LABC): 62 patients had a clinical history of rapidly growing tumours (doubling time less-than-or-equal-to 4 months) and inflammatory signs; conversely, the 47 neglected patients had local inflammation with a longer history of LABC.103 patients were fully evaluable. All patients received the same induction chemotherapy with doxorubicin, vincristine, cyclophosphamide and 5-fluorouracil. After six cycles, locoregional treatment was by radiotherapy if a complete or nearly complete response had been obtained, and total mastectomy, with pre or postoperative radiotherapy, in othercases. The chemotherapy after local treatment comprised of six cyclesfor LABC and 12 cycles for IBC (six without doxorubicin). With a median follow-up of 120 months, the median overall survival (OS) time was 70 months as against 45 months for disease-free survival (DFS). No difference was observed for OS and DFS between LABC and IBC. The regionalrecurrence rate was 24% (15% for radiotherapy alone). 20 factors of potential prognostic significance were evaluated by univariate and multivariate analysis. For DFS and OS, univariate analysis suggested a worse prognostic significance for ''peau d'orange'' appearance of the skin, clinical evidence of node involvement and poor response to chemotherapy after three cycles, on mammographic criteria. The cumulative doseof doxorubicin after three cycles seemed to have a significant effecton OS (P < 0.03) but was too closely correlated with age to draw definite conclusions. In the multivariate analysis, ''peau d'orange'', menopausal staus and clinical node involvement predicted DFS. ''Peau d'orange'' and clinical node involvement also predicted OS. Our results indicate that IBC and LABC do not behave differently when treated with our procedure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:03:40