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Titolo:
DIFFERENCES IN REACTIVITY TO CYCLOSPORINE-A AND INTERFERON-GAMMA OF NORMAL AND HPV-TRANSFORMED KERATINOCYTES
Autore:
MARIONNET AV; LIZARD G; CHIGNOL MC; CHARDONNET Y; SCHMITT D;
Indirizzi:
HOP EDOUARD HERRIOT,INSERM U346,PAVILLON R F-69437 LYON 03 FRANCE HOP EDOUARD HERRIOT,INSERM U346 F-69437 LYON 03 FRANCE HOP BOCAGE,INSERM CJF 9310 F-21000 DIJON FRANCE
Titolo Testata:
Anticancer research
fascicolo: 1, volume: 16, anno: 1996,
pagine: 257 - 267
SICI:
0250-7005(1996)16:1<257:DIRTCA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS TYPE-16; CULTURED HUMAN KERATINOCYTES; RENAL-TRANSPLANT RECIPIENTS; ASSOCIATION; EXPRESSION; INHIBIT; GROWTH; ASSAY; CELLS; SKIN;
Keywords:
CELL GROWTH; CELL CYCLE; NORMAL AND HPV-TRANSFORMED KERATINOCYTES; INTERFERON-GAMMA; CYCLOSPORINE A; CELL MORPHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Marionnet et al., "DIFFERENCES IN REACTIVITY TO CYCLOSPORINE-A AND INTERFERON-GAMMA OF NORMAL AND HPV-TRANSFORMED KERATINOCYTES", Anticancer research, 16(1), 1996, pp. 257-267

Abstract

In humans, cyclosporin A (CsA) avoids organ allograft rejection but induces skin carcinomas after long term immunosuppressive treatment; some of these lesions contain human papillomavirus (HPV) DNA. Interferon-gamma (IFN-gamma) is sometimes used in local treatment of persistent or recurrent lesions in normal population. In vivo, both drugs have aneffect on keratinocytes which remains unclear. Therefore, their effect was studied on in vitro models of normal or HPV-transformed epithelial cell cultures. After exposure of proliferating cells for 1-3 days to 0.5-16 mu g/ml CsA and 5-160 U/ml IFN-gamma, no cytotoxicity was observed; cell growth was inhibited; cell morphology was altered with CsAand cytoplasmic vacuoles were seen in some cells. Changes in the cellcycle were mainly obtained after treatment wlth 8 mu g/ml CsA or 160 U/ml IFN-gamma, with an accumulation in S-phase especially in HPV-transformed cells. Thus, Csa and IFN-gamma affected. normal and HPV-transformed epithelial cells, differently.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:42:30