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Titolo:
IMMUNOHISTOCHEMICAL LOCALIZATION OF AROMATASE AND ITS CORRELATION WITH PROGESTERONE RECEPTORS IN OVARIAN EPITHELIAL TUMORS
Autore:
KITAWAKI J; NOGUCHI T; YAMAMOTO T; YOKOTA K; MAEDA K; URABE M; HONJO H;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,KAMIKYO KU KYOTO 602JAPAN
Titolo Testata:
Anticancer research
fascicolo: 1, volume: 16, anno: 1996,
pagine: 91 - 97
SICI:
0250-7005(1996)16:1<91:ILOAAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; STEROID-RECEPTORS; POSTMENOPAUSAL WOMEN; CYTOCHROME-P-450; CARCINOMA; LOCALIZATION; ESTROGEN; PLACENTA; TUMORS; CANCER;
Keywords:
AROMATASE; IMMUNOHISTOCHEMISTRY; PROGESTERONE RECEPTORS; OVARIAN EPITHELIAL TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J. Kitawaki et al., "IMMUNOHISTOCHEMICAL LOCALIZATION OF AROMATASE AND ITS CORRELATION WITH PROGESTERONE RECEPTORS IN OVARIAN EPITHELIAL TUMORS", Anticancer research, 16(1), 1996, pp. 91-97

Abstract

Aromatase cytochrome P-450 was immunohistochemically localised exclusively in the cytoplasm of neoplastic cells of benign and malignant nonfunctional ovarian tumours, whilst (progesterone receptors (PR) and estrogen receptors) (ER) were localised exclusively in the nuclei of neoplastic cells. Aromatase activity and PR were detected in 68% (17/25) and 32% of the malignant tumours and 82% (22/27) and 67% of the benigntumours, respectively. In postmenopausal tumours, the positivity for PR in malignant tumours was less frequent (p<0.01) than that in benigntumours. The tumours in which both aromatase and PR were positive, were less frequent (p<0.05) in malignant than in benign tumours. Aromatase activity was detected in 100% (8/8) of the PR-positive tumours but in only 68% (9/17) of the PR-negative tumours. With postmenopausal malignant tumours, there was a positive correlation between aromatase activity and PR level (r=0.77, p<0.001). However, there was no significant difference in the positivity for ER. The serum steroid levels did not correlate with the tumour levels of aromatase activity, PR or ER. These findings suggest that aromatase activity is correlated with PR in ovarian tumours of postmenopausal women. In addition to steroid receptor status, aromatase activity may be a useful factor in ovarian cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:50:48