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Titolo:
ANTITUMOR EFFECT OF TNP-470 ON GLIAL TUMORS TRANSPLANTED IN RATS
Autore:
ISOBE N; UOZUMI T; KURISU K; KAWAMOTO K;
Indirizzi:
HIROSHIMA UNIV,SCH MED,DEPT NEUROSURG,MINAMI KU,1-2-3 KASUMI HIROSHIMA 734 JAPAN
Titolo Testata:
Anticancer research
fascicolo: 1, volume: 16, anno: 1996,
pagine: 71 - 76
SICI:
0250-7005(1996)16:1<71:AEOTOG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOGENESIS INHIBITOR TNP-470; CHEMICAL MODIFICATION; CELL-LINES; GROWTH; FUMAGILLIN; AGM-1470;
Keywords:
ANGIOGENESIS; TNP-470; 9-L GLIOSARCOMA; LOSS OF BODY WEIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
N. Isobe et al., "ANTITUMOR EFFECT OF TNP-470 ON GLIAL TUMORS TRANSPLANTED IN RATS", Anticancer research, 16(1), 1996, pp. 71-76

Abstract

Anti-angiogenic agents were be clinically useful for the therapy of solid tumors, as the growth and proliferation of tumors require neovascularization. Previous reports have been made on the antitumor effect of TNP-470, an angiogenic inhibitor, on medulloblastomas implanted subcutaneously into nude mice. The present study was undertaken for the purpose of investigating possible antitumor effects on two model subcutaneous and intracranial tumors transplanted into rats. 9-L gliosarcomaswere transplanted into the left femoral region subcutaneously and theleft frontal region of Fischer 344 female rats, and the TNP-470 was then administered subcutaneously. The rats were divided into two treatment groups and a control group. TNP-470 resulted in dose-dependent inhibition of 9-L gliosarcoma growth and also prolonged survival in treatment groups. Therefore TNP-470 was considered to be effective for the treatment of malignant brain tumors, although it caused dose-dependentdecreases in body weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:24:29