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Titolo:
THE INTERRELATIONSHIP BETWEEN CYTOTOXIN-ASSOCIATED GENE-A, VACUOLATING CYTOTOXIN, AND HELICOBACTER-PYLORI-RELATED DISEASES
Autore:
WEEL JFL; VANDERHULST RWM; GERRITS Y; ROORDA P; FELLER M; DANKERT J; TYTGAT GNJ; VANDERENDE A;
Indirizzi:
UNIV AMSTERDAM,DEPT MED MICROBIOL,ACAD MED CTR,POB 22700 1100 DE AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT GASTROENTEROL,ACAD MED CTR 1100 DE AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT HEPATOL,ACAD MED CTR 1100 DE AMSTERDAM NETHERLANDS
Titolo Testata:
The Journal of infectious diseases
fascicolo: 5, volume: 173, anno: 1996,
pagine: 1171 - 1175
SICI:
0022-1899(1996)173:5<1171:TIBCGV>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMPYLOBACTER-PYLORI; GNOTOBIOTIC PIGLETS; DUODENAL-ULCER; INFECTION; GASTRITIS; TOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.F.L. Weel et al., "THE INTERRELATIONSHIP BETWEEN CYTOTOXIN-ASSOCIATED GENE-A, VACUOLATING CYTOTOXIN, AND HELICOBACTER-PYLORI-RELATED DISEASES", The Journal of infectious diseases, 173(5), 1996, pp. 1171-1175

Abstract

The interrelationship between cytotoxin-associated gene A (CagA), vacuolating cytotoxin (VacA), and Helicobacter pylori-related diseases was investigated in 155 H, pylori-infected patients. Four (7%) of 60 subjects had mixed cagA(+) and cagA(-) H. pylori infections. The H. pylori isolates from 98.3% of 121 patients with anti-CagA antibodies were cagA(+), The occurrence of cagA(+) H. pylori among 76 patients with peptic ulcer disease (PUD) was higher (93.4%) than among 79 patients withfunctional dyspepsia (FD; 64.6%) (odds ratio [OR] = 7.80; P <.001). VacA(+) isolates were isolated from 56.6% of the PUD patients and 35.4%of the FD patients (OR = 2.37; P = .0132), For type I (cagA(+)VacA(+)) isolates, these numbers were 56.6% and 31.6%, respectively (P = .003). Only 4% of the 71 VacA(+) isolates were cagA(-). In addition, 37% of the patients with PUD were infected with cagA(+)VacA(-) H. pylori. chi(2) results did not improve when VacA was entered into the model in the presence of cagA, indicating that only cagA is associated with PUD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:35:04