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Titolo:
HUMAN IMMUNE-RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES - COMPLEMENT-MEDIATED LOCALIZATION PREFERENTIALLY ON CD21-POSITIVE SPLENIC MARGINAL ZONE B-CELLS AND FOLLICULAR DENDRITIC CELLS
Autore:
LLOPIS MJP; HARMS G; HARDONK MJ; TIMENS W;
Indirizzi:
UNIV GRONINGEN,DEPT PATHOL,OOSTERSINGEL 63 9713 EZ GRONINGEN NETHERLANDS UNIV GRONINGEN,DEPT PATHOL 9713 EZ GRONINGEN NETHERLANDS
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 4, volume: 97, anno: 1996,
pagine: 1015 - 1024
SICI:
0091-6749(1996)97:4<1015:HITPP->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LYMPHOCYTES-B; RECEPTOR TYPE-2; CAPSULAR POLYSACCHARIDE; HUMAN SPLEEN; EXPRESSION; ACTIVATION; ANTIGENS; ANTIBODY; SYSTEM; CD21;
Keywords:
CD21; CR-2; FOLLICULAR DENDRITIC CELLS; MARGINAL ZONE; PNEUMOCOCCAL POLYSACCHARIDES; SPLEEN; TI-2 RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.J.P. Llopis et al., "HUMAN IMMUNE-RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES - COMPLEMENT-MEDIATED LOCALIZATION PREFERENTIALLY ON CD21-POSITIVE SPLENIC MARGINAL ZONE B-CELLS AND FOLLICULAR DENDRITIC CELLS", Journal of allergy and clinical immunology, 97(4), 1996, pp. 1015-1024

Abstract

A functionally intact spleen with a marginal zone, containing B cellswith high density of surface C3d-receptors (CD21), is essential for the ability to induce a primary immune response to thymus-independent type 2 (TI-2) antigens. Main representatives of natural TI-2 antigens are capsular pneumococcal polysaccharides (PPSs). In this study the localization of different types of PPS antigen is determined in human spleen tissue. Our findings indicate that a main type of TI-2 antigen, PPS, localizes preferentially in the marginal zone. PPSs show co-localization with C3, presumably C3d, at the surface of strongly CD21+ B cells equipped for rapid activation. This enables a rapid primary humoral response. The other main PPS localization at follicular dendritic cells in germinal centers, relevant for isotype switching of anti-PPS antibodies, does not seem to be dependent on the presence of specific immunoglobulin. This may explain the finding of specific IgG in an early stage after antigenic challenge. It seems likely that complement C3 fragments (likely C3d), bound to PPSs, enable PPS localization at B-cell and follicular dendritic cell surfaces by binding to CD21, the C3d receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:44:25