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Titolo:
LUNG WATER IS INCREASED IN REGIONS OF HIGHER NEUTROPHIL RETENTION AFTER ACUTE BEAD EMBOLIZATION
Autore:
TSANG J; BRUSH B;
Indirizzi:
UNIV BRITISH COLUMBIA,ST PAULS HOSP,PULM RES LAB,1081 BURRARD ST VANCOUVER BC V6Z 1Y6 CANADA
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 80, anno: 1996,
pagine: 1513 - 1519
SICI:
8750-7587(1996)80:5<1513:LWIIIR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-EMBOLISM; BLOOD-FLOW; DOG LUNGS; LEUKOCYTES; EDEMA; MICROEMBOLIZATION; HYPOXEMIA; KINETICS; EXCHANGE; ADHESION;
Keywords:
POLYMORPHONUCLEAR CELLS; EMBOLIC INJURY; INTRAVASCULAR COAGULATION; THROMBIN; EXTRAVASCULAR LUNG WATER; PERMEABILITY PULMONARY EDEMA; REGIONAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Tsang e B. Brush, "LUNG WATER IS INCREASED IN REGIONS OF HIGHER NEUTROPHIL RETENTION AFTER ACUTE BEAD EMBOLIZATION", Journal of applied physiology, 80(5), 1996, pp. 1513-1519

Abstract

Previous reports have shown that neutrophils are retained in the lungafter acute embolization and that these neutrophils play an importantrole in the subsequent formation of permeability pulmonary edema. Thepresent study was designed to test the hypothesis that acute embolic injury results in microvascular damage in lung regions with the greater retention of neutrophils. Seventeen pigs (20 +/- 2 kg) were embolized by injecting polystyrene beads (250 mu m; labeled with I-131) into the right atrium over 5 min. Five pigs, which received no embolic beads, served as controls. Neutrophils (89 +/- 5% pure), isolated on Ficoll-Histopaque gradient, were radiolabeled with In-111-oxine. Twenty minutes after embolization, the radiolabeled neutrophils were injected into the right atrium along with Sr-85-labeled microspheres to mark the initial neutrophil distribution within the lung as well as the regionalpulmonary blood flow at the time of their delivery. The animals were killed 50 min after embolization, and the lungs were removed, frozen over liquid nitrogen, and cut into 60 samples. The data show that afterembolization regional neutrophil retention was inversely related to the regional blood flow but was not affected by the embolic load in thesame region. Regional extravascular lung water was increased in regions of higher neutrophil retention, but the regions with increased edema did not receive a greater embolic load. These results show that microvascular injury occurs in the lung regions with the greatest neutrophil retention and that this increased retention of neutrophils is unrelated to the extent of embolization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:38:39