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Titolo:
PROTOONCOGENE PRODUCTS VAV AND C-CBL ARE INVOLVED IN THE SIGNAL-TRANSDUCTION THROUGH GRB2 ASH IN HEMATOPOIETIC-CELLS/
Autore:
HANAZONO Y; ODAI H; SASAKI K; IWAMATSU A; YAZAKI Y; HIRAI H;
Indirizzi:
UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,HONGO 7-3-1 TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU TOKYO 113 JAPAN KIRIN BREWERY CO LTD,CENT LAB KEY TECHNOL YOKOHAMA KANAGAWA JAPAN
Titolo Testata:
Acta haematologica
fascicolo: 3-4, volume: 95, anno: 1996,
pagine: 236 - 242
SICI:
0001-5792(1996)95:3-4<236:PPVACA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANINE-NUCLEOTIDE EXCHANGE; EPIDERMAL GROWTH-FACTOR; TYROSINE PHOSPHORYLATION; ADAPTER PROTEIN; SH3 DOMAINS; V-CBL; RAS; ASSOCIATION; RECEPTOR; KINASE;
Keywords:
C-CBL; GRB2/ASH; GM-CSF; TYROSINE PHOSPHORYLATION; VAV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hanazono et al., "PROTOONCOGENE PRODUCTS VAV AND C-CBL ARE INVOLVED IN THE SIGNAL-TRANSDUCTION THROUGH GRB2 ASH IN HEMATOPOIETIC-CELLS/", Acta haematologica, 95(3-4), 1996, pp. 236-242

Abstract

Grb2/Ash is composed of one SH2 and two SH3 domains and functions as an adapter linking tyrosine kinase receptors and Ras in fibroblasts. We have investigated the nature of proteins interacting with Grb2/Ash in hematopoietic cells. The product of the vav proto-oncogene (Vav) is expressed exclusively in hematopoietic cells and has guanine nucleotide exchange activity. Here we report that granulocyte/macrophage-colony-stimulating factor (GM-CSF), interleukin-3, and erythropoietin (Epo) induce rapid and transient tyrosine phosphorylation of Vav and that Vav is constitutively associated with the SH3 domain of Grb2/Ash in a human leukemia cell line UT-7. These data implicate Vav in a signaling pathway leading to activation of Ras or Ras-related proteins in hematopoietic cells. Furthermore, we have shown that the protooncogene c-cbl product (c-Cbl) is also tyrosine-phosphorylated by stimulation with GM-CSF or Epo and is constitutively associated with the SH3 domain of Grb2/Ash in UT-7. However, we could not find the homologous regions withguanine nucleotide exchange factors or GTPase-activating proteins in the c-cbl gene. Therefore, Grb2/Ash might also transduce a signal thatis different from the signal leading to the small-G protein regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:03:03