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Titolo:
SIGNIFICANT DECREASE IN PARATHYROID HORMONE-RELATED PROTEIN CONCENTRATIONS IN AMNIOTIC-FLUID WITH LABOR AT TERM BUT NOT PRETERM
Autore:
MITCHELL MD; HUNTER C; DUDLEY DJ; VARNER MW;
Indirizzi:
UNIV AUCKLAND,DEPT PHARMACOL & CLIN PHARMACOL,PRIVATE BAG 92019 AUCKLAND NEW ZEALAND UNIV UTAH,SCH MED,DEPT OBSTET & GYNAECOL SALT LAKE CITY UT 84132
Titolo Testata:
Reproduction, fertility and development
fascicolo: 2, volume: 8, anno: 1996,
pagine: 231 - 234
SICI:
1031-3613(1996)8:2<231:SDIPHP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INFLAMMATORY MEDIATORS; UTERINE CONTRACTION; FRAGMENTS; CELLS; BIOSYNTHESIS; EXPRESSION; CALCIUM; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Mitchell et al., "SIGNIFICANT DECREASE IN PARATHYROID HORMONE-RELATED PROTEIN CONCENTRATIONS IN AMNIOTIC-FLUID WITH LABOR AT TERM BUT NOT PRETERM", Reproduction, fertility and development, 8(2), 1996, pp. 231-234

Abstract

It has been determined whether amniotic fluid concentrations of parathyroid hormone-related protein (PTHrP) change with labour. An evaluation of which cells from intrauterine tissues might produce PTHrP has also been conducted. Amniotic fluid was obtained by amniocentesis from women: (1) at term, not in labour; (2) in normal term labour; (3) in preterm labour, undelivered within one week; (4) in preterm labour, delivered within one week; (5) in preterm labour associated with clinical chorioamnionitis; and (6) who were gestation-matched controls for chorioamnionitis patients-women in this group were similar to those in Group 4 but were different patients. Amnion, chorion, and decidual cells were grown by standard techniques and incubated with interleukin-1 beta (IL-1 beta). PTHrP was assayed in duplicate samples of amniotic fluid or tissue culture media using an immunoradiometric assay. There was a significant reduction in amniotic fluid concentrations of PTHrP during labour at term. Preterm labour was not associated with significant changes in amniotic fluid concentrations of PTHrP although a trend forreduced concentrations was observed. Amnion and chorion produced measurable quantities of PTHrP and rates of production were increased by treatment with IL-1 beta. Decidual cells did not produce detectable amounts of PTHrP. Hence, labour at term is associated with a decrease in amniotic fluid PTHrP concentrations that may reflect reduced amnion production, which in turn may play a permissive or active role in the mechanism(s) of parturition. These data support the view that the mechanisms that control term and preterm labour may be regulated differently.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:52:42