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Titolo:
PORCINE GASTROEPIPLOIC ARTERY AS AN IN-VITRO EXPERIMENTAL-MODEL TO STUDY VASODILATORS IN MICROSURGERY
Autore:
KIM DC; CHEN D; PERROTTA VJ; SHUMAN CA; WENDLING WW; HARAKAL C; MITRA A;
Indirizzi:
TEMPLE UNIV,HLTH SCI CTR,PLAST & RECONSTRUCT SURG SECT,3322 N BROAD ST,3RD FLOOR PHILADELPHIA PA 19140 TEMPLE UNIV,HLTH SCI CTR,PLAST & RECONSTRUCT SURG SECT PHILADELPHIA PA 19140 TEMPLE UNIV,HLTH SCI CTR,DEPT ANESTHESIOL PHILADELPHIA PA 19140 TEMPLE UNIV,HLTH SCI CTR,DEPT PHARMACOL PHILADELPHIA PA 19140
Titolo Testata:
Annals of plastic surgery
fascicolo: 5, volume: 36, anno: 1996,
pagine: 502 - 507
SICI:
0148-7043(1996)36:5<502:PGAAAI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; SKIN FLAP SURVIVAL; CALCIUM-ANTAGONISTS; VERAPAMIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Kim et al., "PORCINE GASTROEPIPLOIC ARTERY AS AN IN-VITRO EXPERIMENTAL-MODEL TO STUDY VASODILATORS IN MICROSURGERY", Annals of plastic surgery, 36(5), 1996, pp. 502-507

Abstract

Arterial vasospasm is a common problem in microsurgery. This pharmacological study compares seven vasodilators-lidocaine, papaverine, nicardipine, verapamil, diltiazem, sodium nitroprusside, and hydralazine-for their efficacy and potency in an experimental model of vasospasm. Porcine gastroepiploic arteries were cut into rings to measure isometrictension development in vitro. The arteries were preconstricted with endothelin-1, a stable thromboxane A(2) analogue, norepinephrine, or potassium, and then exposed to increasing concentrations of each vasodilator. Every vasodilator except hydralazine and sodium nitroprusside was efficacious in producing near-maximal relaxation of arteries preconstricted with any vasospastic substance. The five efficacious vasodilators differed markedly in potency, as reflected in the concentrations producing half-maximal relaxation. The order of potency was nicardipineless than or equal to verapamil or diltiazem < papaverine < lidocaine. This study suggests that nicardipine would be the most potent vasodilator for systemic or direct intra-arterial administration. Papaverineand lidocaine, in concentrations employed clinically, were both efficacious as topical vasodilators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:25:57