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Titolo:
ANGIOTENSIN-II MODULATES GLOMERULAR CAPILLARY PERMSELECTIVITY IN RAT ISOLATED-PERFUSED KIDNEY
Autore:
LAPINSKI R; PERICO N; REMUZZI A; SANGALLI F; BENIGNI A; REMUZZI G;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,VIA GAVAZZENI 11 I-24125 BERGAMO ITALY MARIO NEGRI INST PHARMACOL RES I-24125 BERGAMO ITALY OSPED RIUNITI BERGAMO,DIV NEPHROL & DIALYSIS I-24100 BERGAMO ITALY
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 5, volume: 7, anno: 1996,
pagine: 653 - 660
SICI:
1046-6673(1996)7:5<653:AMGCPI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITION; PLATELET-ACTIVATING-FACTOR; REDUCED RENAL MASS; DIABETIC NEPHROPATHY; RECEPTOR ANTAGONIST; SIZE-SELECTIVITY; BARRIER; HYPERTENSION; FILTRATION; INJURY;
Keywords:
PROTEINURIA; ANGIOTENSIN RECEPTOR BLOCKADE; FICOLL CLEARANCE; SIZE-SELECTIVE PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R. Lapinski et al., "ANGIOTENSIN-II MODULATES GLOMERULAR CAPILLARY PERMSELECTIVITY IN RAT ISOLATED-PERFUSED KIDNEY", Journal of the American Society of Nephrology, 7(5), 1996, pp. 653-660

Abstract

Studies in experimental animals and humans have documented that inhibition of the renin-angiotensin system by angiotensin-converting enzymeinhibitors reduces urinary protein excretion rate and retards the development of renal injury, Here we sought to investigate whether angiotensin II (All) modified the size-selective properties to macromolecules of the glomerular capillary barrier in isolated perfused rat kidney preparation. Compared with basal values, continuous All infusion into the renal artery at the rate of 3 or 8 ng/min, but not at 0.6 ng/min, induced a progressive and significant increase in urinary protein excretion rate. Evaluation of the sieving properties of the glomerular barrier by fractional clearance of polydisperse Ficoll showed that All significantly enhanced the filtration of tracer molecules of radii greater than or equal to 34 Angstrom. All-induced changes in urinary protein excretion rate and in Ficoll fractional clearance were completely prevented by pretreatment with the specific All Type 1 receptor antagonist SR 47436.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 09:45:59