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Titolo:
ANTIOXIDANTS IN PERIPHERAL-NERVE
Autore:
ROMERO FJ;
Indirizzi:
UNIV VALENCIA,SCH MED & DENT,DEPT PHYSIOL,EXPT TOXICOL & NEUROTOXICOLUNIT,AV BLASCO IBANEZ 17 E-46010 VALENCIA SPAIN
Titolo Testata:
Free radical biology & medicine
fascicolo: 7, volume: 20, anno: 1996,
pagine: 925 - 932
SICI:
0891-5849(1996)20:7<925:AIP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; NA+-K+-ATPASE; EXPERIMENTAL DIABETIC NEUROPATHY; AMYOTROPHIC-LATERAL-SCLEROSIS; FRIEND-ERYTHROLEUKEMIA CELLS; OXYGEN FREE-RADICALS; SCIATIC-NERVE; LIPID-PEROXIDATION; SUPEROXIDE-DISMUTASE; GLUTATHIONE CONTENT;
Keywords:
FREE RADICALS; GLUTATHIONE; 4-HYDROXYNONENAL; SCIATIC NERVE; ANTIOXIDANTS; PROTEIN KINASE C; NEUROPATHIES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
112
Recensione:
Indirizzi per estratti:
Citazione:
F.J. Romero, "ANTIOXIDANTS IN PERIPHERAL-NERVE", Free radical biology & medicine, 20(7), 1996, pp. 925-932

Abstract

Oxidative stress and antioxidants have been related in a wide varietyof ways with nervous tissue, This review attempts to gather the most relevant information related to a) the antioxidant status in non pathologic nervous tissue; b) the hypothesis and evidence for oxidative stress (considered as the disequilibrium between prooxidants and antioxidants in the cell) as the responsible mechanism of diverse neurologicaldiseases; and c) the correlation between antioxidant alterations and neural function, in different experimental neuropathies. Decreased antioxidant availability has been observed in different neurological disorders in the central nervous system, for example, Parkinson's disease,Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, cerebral ischaemia, etc. Moreover, the experimental manipulation of the antioxidant defense has led in some cases to interesting experimental models in which electrophysiological alterations are associated with the metabolic modifications induced. In view of the electrophysiological andbiochemical effects of some protein kinase C inhibitors on different neural experimental models, special attention is dedicated to the roleof this kinase in peripheral nervous tissue. The nervous tissue, central as well as peripheral, has two main special features that are certainly related to its antioxidant metabolism: the lipid-enriched membrane and myelin sheaths, and cellular excitability. The former explains the importance of the glutathione (GSH)-conjugating activity towards 4-hydroxy-nonenal, a biologically active product of lipid peroxidation,present in nervous tissue and in charge of its inactivation, The impairment of the latter by oxidative damage or experimental manipulation of antioxidant metabolism is discussed. Work on different experimentalneuropathies from author's laboratory has been primarily used to provide information about the involvement of free radical damage and antioxidants in peripheral nerve metabolic and functional impairment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:38:08