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Titolo:
DESENSITIZATION OF NEUROTENSIN-INDUCED PHOSPHOINOSITIDE HYDROLYSIS INTRANSFECTED CHO CELLS
Autore:
HERMANS E; MALOTEAUX JM;
Indirizzi:
UNIV CATHOLIQUE LOUVAIN,LAB NEUROCHIM,AVE E MOUNIER 53 B-1200 BRUSSELS BELGIUM
Titolo Testata:
Biochemical pharmacology
fascicolo: 12, volume: 51, anno: 1996,
pagine: 1749 - 1752
SICI:
0006-2952(1996)51:12<1749:DONPHI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWN-REGULATION; CLONE N1E-115; NEUROMEDIN-N; RECEPTOR; MOBILIZATION; EXPRESSION; BINDING; NEURONS; BRAIN;
Keywords:
NEUROTENSIN RECEPTOR; PHOSPHOINOSITIDE HYDROLYSIS; DESENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E. Hermans e J.M. Maloteaux, "DESENSITIZATION OF NEUROTENSIN-INDUCED PHOSPHOINOSITIDE HYDROLYSIS INTRANSFECTED CHO CELLS", Biochemical pharmacology, 51(12), 1996, pp. 1749-1752

Abstract

The regulation of neurotensin-induced phosphoinositide turnover was studied in transfected CHO cells expressing the rat neurotensin receptor. Stimulation of these cells with neurotensin resulted in an important, but transient, increase in inositol phosphate cell content. Preincubation of the cells with neurotensin dramatically decreased their response to further stimulation. This diminution, which was rime-dependentand not related to the availability of phospholipase C substrate, is though to reflect a progressive homologous desensitization of the recombinant neurotensin receptor.

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Documento generato il 30/09/20 alle ore 09:02:30