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Titolo:
TUMOR-NECROSIS-FACTOR EFFECTS ON ASCITES FORMATION IN AN EXPERIMENTALTUMOR-MODEL
Autore:
BEHAMMER W; KLUGE M; RUSCHOFF J; MANNEL DN;
Indirizzi:
UNIV REGENSBURG,INST PATHOL TUMORIMMUNOL D-93042 REGENSBURG GERMANY UNIV REGENSBURG,INST PATHOL TUMORIMMUNOL D-93042 REGENSBURG GERMANY KNOLL AG,DEPT ONCOL D-67008 LUDWIGSHAFEN GERMANY
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 5, volume: 16, anno: 1996,
pagine: 403 - 408
SICI:
1079-9907(1996)16:5<403:TEOAFI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT ASCITES; OVARIAN-CANCER; FACTOR-ALPHA; INTERFERON; CYTOKINES; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
W. Behammer et al., "TUMOR-NECROSIS-FACTOR EFFECTS ON ASCITES FORMATION IN AN EXPERIMENTALTUMOR-MODEL", Journal of interferon & cytokine research, 16(5), 1996, pp. 403-408

Abstract

In humans, treatment of malignant ascites with bolus TNF leads to resolution of the ascites, In an experimental model NMRI nude mice were inoculated intraperitoneally with human NIH-OVCAR3 adenocarcinoma cells, resulting in production of ascites and intraperitoneal tumor growth,Ascites formation and tumor growth after IP injection of recombinant human TNF was determined, Depending on the treatment schedule, a dual effect of TNF on the development of ascites was seen, Doses of TNF (1-10 mu g/g) given once per week completely prevented ascites production, whereas the same doses of TNF given on a daily schedule induced enhanced ascites formation in an inverse TNF dose relationship, The area of tumor cell-covered peritoneal lining corresponded to these findings,indicating a correlation of tumor mass with ascites production, In anattempt to prevent renewal of ascites after drainage, neither inhibition nor enhancement in ascites production was seen when TNF was given five times per week, However, doses of 10 mu g/g of TNF once per week led to almost complete inhibition of ascites reappearance, Histological examination of animals that received repeated TNF treatment demonstrated chronic peritonitis with strong stromal proliferation, angiogenesis, and increased adhesion of tumor cells to the peritoneum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:25:10