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Titolo:
PARTIAL INHIBITION OF VESICULAR STOMATITIS-VIRUS BY THE INTERFERON-INDUCED HUMAN 9-27-PROTEIN
Autore:
ALBER D; STAEHELI P;
Indirizzi:
UNIV FREIBURG,DEPT VIROL,HERMANN HERDER STR 11 D-79008 FREIBURG GERMANY UNIV FREIBURG,ABT VIROL,INST MED MIKROBIOL & HYG D-79008 FREIBURG GERMANY
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 5, volume: 16, anno: 1996,
pagine: 375 - 380
SICI:
1079-9907(1996)16:5<375:PIOVSB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSTITUTIVE EXPRESSION; MEMBRANE-PROTEIN; INFLUENZA-VIRUS; CELL-GROWTH; GENE; RESISTANCE; CESSATION; NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D. Alber e P. Staeheli, "PARTIAL INHIBITION OF VESICULAR STOMATITIS-VIRUS BY THE INTERFERON-INDUCED HUMAN 9-27-PROTEIN", Journal of interferon & cytokine research, 16(5), 1996, pp. 375-380

Abstract

To determine whether the interferon-induced 9-27 protein of human cells contributes to the antiviral state, we expressed the 9-27 cDNA under the control of a constitutive promoter and assayed transfected cellsfor enhanced virus resistance, The intracellular distribution of 9-27resembled that of cytoskeleton-associated proteins, Analysis at the single-cell level by indirect immunofluorescence revealed that mouse cells expressing 9-27 were less permissive for vesicular stomatitis virus than control cells not expressing 9-27, No significant inhibition ofinfluenza virus was observed. When tested in parallel, 9-27 was foundto have less powerful antiviral activity toward vesicular stomatitis virus than the interferon-induced MxA protein, Thus, 9-27 joins the family of interferon-induced proteins with intrinsic antiviral activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:22:57