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Titolo:
INFECTIOUS SUSCEPTIBILITY AND SEVERE DEFICIENCY OF LEUKOCYTE ROLLING AND RECRUITMENT IN E-SELECTIN AND P-SELECTIN DOUBLE MUTANT MICE
Autore:
BULLARD DC; KUNKEL EJ; KUBO H; HICKS MJ; LORENZO I; DOYLE NA; DOERSCHUK CM; LEY K; BEAUDET AL;
Indirizzi:
BAYLOR COLL MED,DEPT MOL & HUMAN GENET,ONE BAYLOR PLAZA,T619 HOUSTON TX 77030 BAYLOR COLL MED,DEPT MOL & HUMAN GENET HOUSTON TX 77030 BAYLOR COLL MED,DEPT PATHOL HOUSTON TX 77030 HOWARD HUGHES MED INST HOUSTON TX 77030 UNIV VIRGINIA,SCH MED,DEPT BIOMED ENGN CHARLOTTESVILLE VA 22908 INDIANA UNIV,SCH MED,SECT PEDIAT PULM INDIANAPOLIS IN 46202
Titolo Testata:
The Journal of experimental medicine
fascicolo: 5, volume: 183, anno: 1996,
pagine: 2329 - 2336
SICI:
0022-1007(1996)183:5<2329:ISASDO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION DEFICIENCY; CHEMOTACTIC FACTORS; NEUTROPHIL; LIGAND; MAC-1; MOLECULE; LFA-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Bullard et al., "INFECTIOUS SUSCEPTIBILITY AND SEVERE DEFICIENCY OF LEUKOCYTE ROLLING AND RECRUITMENT IN E-SELECTIN AND P-SELECTIN DOUBLE MUTANT MICE", The Journal of experimental medicine, 183(5), 1996, pp. 2329-2336

Abstract

During the initial phase of the inflammatory response, leukocytes marginate and roll along the endothelial surface, a process mediated largely by the selectins and their ligands. Mice with mutations in individual selectins show no spontaneous disease and have mild or negligible deficiencies of inflammatory responses. In contrast, we find that micewith null mutations in both endothelial selectins (P and E) develop aphenotype of leukocyte adhesion deficiency characterized by mucocutaneous infections, plasma cell proliferation, hypergammaglobulinemia, severe deficiencies of leukocyte rolling in cremaster venules with or without addition of TNF-alpha, and an absence of neutrophil emigration at 4 h in response to intraperitoneal Streptococcus pneumoniae peritonitis. These mice provide strong evidence for the functional importance of selectins in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:35:47