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Titolo:
STRESS INJECTION PROTOCOLS FOR MYOCARDIAL SCINTIGRAPHY WITH TC-99(M)-SESTAMIBI COMPARED WITH TL-201 - IMPLICATIONS OF EARLY POSTSTRESS KINETICS/
Autore:
HURWITZ GA; BLAIS M; POWE JE; CHAMPAGNE CL;
Indirizzi:
VICTORIA HOSP,DEPT NUCL MED,375 SOUTH ST LONDON ON N6A 4G5 CANADA
Titolo Testata:
Nuclear medicine communications
fascicolo: 5, volume: 17, anno: 1996,
pagine: 400 - 409
SICI:
0143-3636(1996)17:5<400:SIPFMS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; METHOXY-ISOBUTYL-ISONITRILE; TC-99M SESTAMIBI; PERFUSION SCINTIGRAPHY; DIPYRIDAMOLE; EXERCISE; REST; TOMOGRAPHY; IMAGES; MIBI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Hurwitz et al., "STRESS INJECTION PROTOCOLS FOR MYOCARDIAL SCINTIGRAPHY WITH TC-99(M)-SESTAMIBI COMPARED WITH TL-201 - IMPLICATIONS OF EARLY POSTSTRESS KINETICS/", Nuclear medicine communications, 17(5), 1996, pp. 400-409

Abstract

Stress/injection protocols developed for myocardial perfusion imagingwith Tl-201 may not be optimal for Tc-99(m)-sestamibi (MIBI), an agent with lower myocardial extraction and higher abdominal uptake; prolongation of exercise after radiotracer injection might improve these relative drawbacks of MIBI. We compared the kinetics of MIBI and Tl-201 by acquiring dynamic planar images for 5-7 min after a bolus injection (n = 180 studies) with stress performed by supine bicycle exercise alone, intravenous dipyridamole or combined stress. Routine or prolonged protocols involved continuation of exercise for 1 or 2.5 min respectively after tracer appearance in the heart. Subsequently, the perfusion images obtained were categorized as normal or showing significant defects. Myocardial uptake of MIBI, normalized for injected dose, body weight and camera sensitivity, was only 40% of that for Tl-201; there were no differences based on test mode or scan result for either perfusion tracer. During the second minute after injection, the cavity/myocardial ratios, an index of blood pool activity, were elevated with MIBI by 25% when compared with Tl-201 (p < 0.001). During the third minute, cavity activity was again higher with MIBI, but only in those subjectswith abnormal scans. The prolonged exercise phase did not prevent progressive accumulation in the abdomen, but did allow cavity levels to decline before termination of exercise. The prolonged protocol may ensure that myocardial uptake of MIBI is completed during peak blood flow,and therefore is recommended for stress with exercise or with dipyridamole and exercise in combination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:11:56