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Titolo:
EFFICIENT DESIGNS FOR TESTING NEW AGENTS AND REGIMENS
Autore:
ARDIZZONI A;
Indirizzi:
IST NAZL RIC CANC,DEPT MED ONCOL 1,VIALE BENEDETTO XV 10 I-16132 GENOA ITALY
Titolo Testata:
Chest
fascicolo: 5, volume: 109, anno: 1996, supplemento:, S
pagine: 83 - 86
SICI:
0012-3692(1996)109:5<83:EDFTNA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; II CLINICAL-TRIALS; COMBINATION CHEMOTHERAPY; CISPLATIN; MITOMYCIN; IFOSFAMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A. Ardizzoni, "EFFICIENT DESIGNS FOR TESTING NEW AGENTS AND REGIMENS", Chest, 109(5), 1996, pp. 83-86

Abstract

Current clinical chemotherapy trial procedures in non-small cell lungcancer (NSCLC) require large numbers of patients and last up to 10 years before providing results that are often disappointing, Different designs are available that offer the advantages of smaller numbers of patients, shorter duration, and earlier identification of ineffective or highly active agents and regimens. An alternative method is proposed, combining phase II screening, randomized phase II studies, and multicenter, comparative, randomized phase III trials, Issues under discussion include the combined study in phase II of different disease stagesand the need for recruitment to larger trials.

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Documento generato il 29/03/20 alle ore 13:53:32