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Titolo:
EFFECTS OF ETHANOL FEEDING AND MALNUTRITION ON COLLAGEN SYNTHESIZING AND DEGRADING ENZYMES IN RAT PANCREAS
Autore:
LOPEZ JM; IMPERIAL S; VALDERRAMA R; GIMENEZ A; PARES A; CABALLERIA J; NAVARRO S;
Indirizzi:
HOSP CLIN BARCELONA,GASTROENTEROL SERV,C VILLARROEL 170 E-08036 BARCELONA SPAIN HOSP CLIN BARCELONA,GASTROENTEROL SERV E-08036 BARCELONA SPAIN UNIV BARCELONA,DEPT BIOCHEM & PHYSIOL BARCELONA SPAIN HOSP CLIN BARCELONA,LIVER UNIT E-08036 BARCELONA SPAIN HOSP CLIN BARCELONA,ALCOHOL UNIT E-08036 BARCELONA SPAIN
Titolo Testata:
Alcohol
fascicolo: 3, volume: 13, anno: 1996,
pagine: 227 - 231
SICI:
0741-8329(1996)13:3<227:EOEFAM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL;
Keywords:
ETHANOL; MALNUTRITION; COLLAGEN; PANCREAS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Lopez et al., "EFFECTS OF ETHANOL FEEDING AND MALNUTRITION ON COLLAGEN SYNTHESIZING AND DEGRADING ENZYMES IN RAT PANCREAS", Alcohol, 13(3), 1996, pp. 227-231

Abstract

This study was performed to delineate the combined effects of a low-fat diet and chronic ethanol ingestion on collagen metabolism in rat pancreas. Rats fed a very low-fat diet (5% of total calories as lipid) for 12 weeks developed malnutrition as judged by weight loss (-33% of the initial body weight) and low serum albumin and amylase levels. The pancreas of malnourished rats showed increased collagenase activity with respect to animals fed a 35% lipid diet (p < 0.05). Hydroxyproline content was higher in the pancreas of malnourished rats and collagenase activity correlated well with hydroxyproline content (r = 0.57, p = 0.0013). Ethanol feeding for 12 weeks, regardless of the nutritional state of the rats, did not change the synthesis and degradation rates of collagen in the pancreas. The present study suggests that malnutrition may have profound effects on collagen metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:34:46