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Titolo:
A PARADOX OF THROMBOGENESIS BY STREPTOKINASE AND ITS PREVENTION BY ILOPROST AND CAMONAGREL
Autore:
KORBUT R; GRYGLEWSKI RJ;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,CHAIR PHARMACOL,DEPT PHARMACOL,16 GRZEGORZECKA PL-31531 KRAKOW POLAND
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 3, volume: 18, anno: 1996,
pagine: 167 - 174
SICI:
0379-0355(1996)18:3<167:APOTBS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; ACUTE MYOCARDIAL-INFARCTION; PLATELET ACTIVATION; THROMBIN ACTIVITY; THROMBOLYTIC THERAPY; AGGREGATION; GENERATION; FIBRINOLYSIS; MECHANISM; INVIVO;
Keywords:
STREPTOKINASE; THROMBORESISTANCE; THROMBOGENESIS; THROMBOLYSIS; PROSTACYCLIN; ILOPROST; ASPIRIN; PLATELETS; THROMBOXANE SYNTHASE INHIBITION; CAMONAGREL; NITRIC OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R. Korbut e R.J. Gryglewski, "A PARADOX OF THROMBOGENESIS BY STREPTOKINASE AND ITS PREVENTION BY ILOPROST AND CAMONAGREL", Methods and findings in experimental and clinical pharmacology, 18(3), 1996, pp. 167-174

Abstract

Here we report that streptokinase is responsible for forming thrombi both in vitro on blood-superfused endothelial cells of rabbit aorta and in vivo on blood-superfused collagen strips in extracorporal circulation of anesthetized cats. This short-lasting paradoxical thrombogenicphase is followed by the expected long-lasting thrombolysis. The biphasic action of streptokinase occurred in vitro at concentrations of 100-2000 U/ml land in vivo at doses of 1000-3000 U/kg i.v. Both phases are mediated by endogenous plasmin as evidenced by deleting the streptokinase-induced thrombogenesis and thrombolysis following pretreatment with epsilon-aminocaproic acid or aprotinin. On the other hand, selective block of the paradoxial thrombogenesis was achieved after pretreatment with camonagrel, a thromboxane synthase inhibitor which raises plasma levels of endogenous prostacyclin, or with iloprost, a stable analog of prostacyclin. It is suggested that endogenous or exogenous prostacyclin inhibits activation of platelets by plasmin, and hence the thrombogenesis by streptokinase is abolished, while the beneficial thrombolytic action of streptokinase is augmented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 07:58:36