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Titolo:
GENETICS OF LDL SUBCLASS PHENOTYPES IN WOMEN TWINS - CONCORDANCE, HERITABILITY, AND COMMINGLING ANALYSIS
Autore:
AUSTIN MA; NEWMAN B; SELBY JV; EDWARDS K; MAYER EJ; KRAUSS RM;
Indirizzi:
UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL,SC-36 SEATTLE WA 98195 KAISER PERMANENTE MED CARE PROGRAM,DIV RES OAKLAND CA 00000 LAWRENCE BERKELEY LAB,DIV RES MED & RADIAT BIOPHYS,MOLEC MED RES PROGRAM BERKELEY CA 94720 UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL CHAPEL HILL NC 27514
Titolo Testata:
Arteriosclerosis and thrombosis
fascicolo: 5, volume: 13, anno: 1993,
pagine: 687 - 695
SICI:
1049-8834(1993)13:5<687:GOLSPI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY DISEASE; APOLIPOPROTEIN-B; MOLECULAR-WEIGHT; HEART-DISEASE; RISK-FACTORS; NHLBI TWIN; PATTERNS; SUBFRACTION; HETEROGENEITY;
Keywords:
CHOLESTEROL; CORONARY HEART DISEASE; GENETICS; HERITABILITY; LDL; TWINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Austin et al., "GENETICS OF LDL SUBCLASS PHENOTYPES IN WOMEN TWINS - CONCORDANCE, HERITABILITY, AND COMMINGLING ANALYSIS", Arteriosclerosis and thrombosis, 13(5), 1993, pp. 687-695

Abstract

Low density lipoprotein (LDL) subclass phenotype B, characterized by a predominance of small LDL as determined by gradient gel electrophoresis, has been associated with increased risk of coronary heart diseaseand an atherogenic lipoprotein profile. Previous studies employing complex segregation analysis have demonstrated a major, single gene effect on the inheritance of this phenotype in families. Recently, linkagebetween this phenotype and variation at the LDL receptor locus on chromosome 19 has been reported. However, variation in LDL subclass phenotypes has also been associated with age, gender, diabetes status, beta-blocker medication, and diet. The present study further evaluates therelative importance of genetic and nongenetic influences on LDL subclass phenotypes and on LDL peak particle diameter (as a reflection of the size of the major LDL subclass) in monozygotic and dizygotic women twin pairs. The analysis is based on 203 monozygotic and 145 dizygoticpairs of adult female twins who participated in the second examination of the Kaiser Permanente Women Twins Study. The average age was 51 years at this exam and 90% were white. Concordance analysis revealed that monozygotic cotwins shared LDL subclass phenotypes more frequently than dizygotic cotwins, and this was confirmed using logistic regression analysis after controlling for potential confounding factors. Heritability analyses suggested that approximately one third to one half ofthe variation in LDL peak particle diameter, a continuous variable reflecting LDL size, could be attributed to genetic influences. Commingling analysis of the frequency distribution of LDL peak particle diameter identified three distinct subgroups of subjects, one of which corresponded to those subjects with LDL subclass phenotype B. This result could reflect the presence of a major gene effect on LDL size. These analyses in women twins demonstrate substantial genetic influences on LDL size heterogeneity, confirming previous studies in families. In addition, significant nongenetic factors are also apparently operating andthus could provide opportunities for targeted intervention to reduce coronary heart disease risk.

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Documento generato il 24/11/20 alle ore 14:01:32