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Titolo:
ATTENUATING EFFECT OF CASTRATION OR ESTROGEN ADMINISTRATION ON GLOMERULAR INJURY IN ADRIAMYCIN-INDUCED NEPHROPATHY OF RATS
Autore:
OHTSUKA N; SAKEMI T; TOMIYOSHI Y; MORITO F;
Indirizzi:
SAGA MED SCH,DEPT INTERNAL MED SAGA 849 JAPAN
Titolo Testata:
Nephrology
fascicolo: 1, volume: 2, anno: 1996,
pagine: 45 - 52
SICI:
1320-5358(1996)2:1<45:AEOCOE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAI RATS; SCLEROSIS; PROTEINURIA; GLOMERULOSCLEROSIS; MODEL; MACROMOLECULES; DISEASE; LESIONS;
Keywords:
ADRIAMYCIN NEPHROPATHY; CASTRATION; GLOMERULOSCLEROSIS; ESTROGEN; SEX-RELATED LOW MOLECULAR WEIGHT PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N. Ohtsuka et al., "ATTENUATING EFFECT OF CASTRATION OR ESTROGEN ADMINISTRATION ON GLOMERULAR INJURY IN ADRIAMYCIN-INDUCED NEPHROPATHY OF RATS", Nephrology, 2(1), 1996, pp. 45-52

Abstract

To clarify the role of sex-related factors in the development of focal segmental glomerulosclerosis (FSGS) we investigated the effect of castration or oestrogen administration in adriamycin (ADR)-induced nephropathy of Sprague-Dawley rats. At 5 weeks of age, group 1 (control group) and group 3 were sham-operated and group 2 was castrated. Adriamycin 2 mg/kg was administered intravenously to all rats at 8 weeks of age twice at a 20-day interval. Group 3 was administered 0.2 mg oestrogen subcutaneously once a month. Bodyweight (BW) and urinary protein were measured every 4 weeks from 15 to 23 weeks of age. Blood pressure weeks of age. Adriamycin induced massive proteinuria in group 1, whereascastration or oestrogen significantly attenuated proteinuria, accompanied by a significant reduction of urinary sex-related low molecular weight (LMW) protein. The glomerulosclerosis index was significantly higher in the control group than in the castrated group or oestrogen-treated group. Attenuation in glomerular injury was more associated with reduction of urinary sex-related LMW protein than the reduction of serum testosterone. These observations suggest that sex-related factors, such as a sex-related LMW protein, influenced by castration or oestrogen administration may play a contributory role in the development of glomerulosclerosis in ADR-induced nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:25:43