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Titolo:
INCREASED EXPRESSION OF SCAVENGER RECEPTOR-TYPE-I GENE IN HUMAN PERIPHERAL-BLOOD FROM HYPERLIPIDEMIC PATIENTS DETERMINED BY QUANTITATIVE ADDITIVE RT-PCR
Autore:
VILLANOVA JG; LUCENA JLD; ARCAS NF; ENGEL AR;
Indirizzi:
UNIV MALAGA,FAC MED,DEPT BIOCHEM & MOLEC BIOL E-29080 MALAGA SPAIN UNIV MALAGA,FAC MED,DEPT BIOCHEM & MOLEC BIOL E-29080 MALAGA SPAIN
Titolo Testata:
Biochimica et biophysica acta, L. Lipids and lipid metabolism
fascicolo: 2, volume: 1300, anno: 1996,
pagine: 135 - 141
SICI:
0005-2760(1996)1300:2<135:IEOSRG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; FUNCTIONAL-CHARACTERISTICS; CHOLESTEROL DEPOSITION; ENDOTHELIAL-CELLS; FOAM CELLS; ATHEROSCLEROSIS; HYPERCHOLESTEROLEMIA; DEGRADATION; BINDING;
Keywords:
MACROPHAGE; MONOCYTE; HYPERLIPIDEMIA; ATHEROSCLEROSIS; SCAVENGER RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Villanova et al., "INCREASED EXPRESSION OF SCAVENGER RECEPTOR-TYPE-I GENE IN HUMAN PERIPHERAL-BLOOD FROM HYPERLIPIDEMIC PATIENTS DETERMINED BY QUANTITATIVE ADDITIVE RT-PCR", Biochimica et biophysica acta, L. Lipids and lipid metabolism, 1300(2), 1996, pp. 135-141

Abstract

The scavenger receptors type I and II are mediators for the binding and uptake of chemically modified lipoproteins and are restricted to cells of monocyte origin. These receptors are highly expressed during the process of monocyte to macrophage differentiation. Quantitative mRNAlevels of scavenger receptors from peripheral blood mononuclear cellshave been analyzed in 29 hyperlipidemic patients and 15 healthy controls. Macrophage scavenger receptor isoforms transcripts were studied in circulating peripheral blood mononuclear cells with a modified RT-PCR method based on the use of a non-modified internal standard and a mathematical logistic adjustment of the standard curve. This method makes it feasible to study the variation in the expression of the scavenger receptors gene in peripheral blood during different physiopathological conditions. We studied the expression of the scavenger receptors gene in different blood cell lines and was present in only those of monocytic origin. The results have shown evidence that levels of scavengerreceptor type I transcripts were proportional to apoB/cholesterol levels whereas type II receptors did not show any transcriptional variability. These findings suggest that the cholesterol level exerts a selective up-regulation of the scavenger receptor type I which is detectable by the induced increment of circulating monocytes in the blood of hyperlipidemic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 14:35:37