Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE DEPLETION OF MONOAMINES BLOCKS THE SYMPATHOINHIBITORY RESPONSE TOCOCAINE
Autore:
ABRAHAMS TP; FAUST ML; VARNER KJ;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL & EXPTL THERAPEUT,1901 PERDIDO ST NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL & EXPTL THERAPEUT NEW ORLEANS LA 70112
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 3, volume: 58, anno: 1996,
pagine: 170 - 176
SICI:
0165-1838(1996)58:3<170:TDOMBT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; CONSCIOUS RATS; SYMPATHOEXCITATORY NEURONS; SQUIRREL-MONKEYS; BRAIN-STEM; SYSTEM; MECHANISMS; AREA; STIMULATION; CLONIDINE;
Keywords:
COCAINE; RAT; SYMPATHETIC NERVE ACTIVITY; RESERPINE; ALPHA-METHYL-P-TYROSINE; BLOOD PRESSURE; HEART RATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Abrahams et al., "THE DEPLETION OF MONOAMINES BLOCKS THE SYMPATHOINHIBITORY RESPONSE TOCOCAINE", Journal of the autonomic nervous system, 58(3), 1996, pp. 170-176

Abstract

Recent studies have shown that cocaine decreases, rather than increases sympathetic nerve discharge (SND). Whether these sympathoinhibitoryresponses are the result of cocaine's actions on monoaminergic transmission (i.e. blockade of neuronal uptake or stimulation of transmitterrelease) or its local anesthetic actions is not known. The purpose ofthe present study was to determine the degree to which cocaine's actions on monoaminergic transmission are involved in mediating the sympathoinhibitory response to this drug. We examined the mean arterial pressure, heart rate and splanchnic sympathetic nerve responses elicited by cocaine (1 mg/kg, i.v.) in pentobarbital-anesthetized rats depleted of monoamines. Monoamines were depleted by administering reserpine (10mg/kg, i.p.) either 24, or 48 and 24 h before the experiment. The rats were also given alpha-methyl-p-tyrosine (200 mg/kg, i.p.) 2 h beforethe experiment. Vehicle-treated rats served as controls. Depletion ofmonoamines markedly reduced resting arterial pressure and heart rate and significantly attenuated the presser response and tachycardia elicited by tyramine (1 mg/kg, i.v.). In control rats, cocaine elicited marked (- 64 +/- 4%) and prolonged (44 +/- 4 min) decreases in SND. The magnitude (- 34 +/- 11%) and duration (23 +/- 6 min) of these responses were significantly attenuated after 1 day of monoamine depletion. After 2 days of depletion, the sympathoinhibitory response was abolishedand was replaced by a small, brief increase in SND (10 +/- 3%). The presser responses were similar in control and depleted rats, while the bradycardic response (- 33 +/- 4 bpm) was significantly reduced after 1 and 2 days of monoamine depletion to - 20 +/- 3 and - 15 +/- 2 bpm, respectively. We conclude that a functionally intact monoaminergic system is essential for the sympathoinhibitory response to cocaine. Whether the presser responses result from a non-monoaminergic or a reserpine and/or alpha-methyl-p-tyrosine resistant catecholaminergic mechanismis unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:42:08