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Titolo:
DETERMINANTS OF SURVIVAL FOLLOWING THE DIAGNOSIS OF ESOPHAGEAL ADENOCARCINOMA (UNITED-STATES)
Autore:
FARROW DC; VAUGHAN TL;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL,DEPT PUBL HLTH SCI,1124 COLUMBIA ST,MP-474 SEATTLE WA 98104 WASHINGTON UNIV,SCH PUBL HLTH & COMMUNITY MED SEATTLE WA 00000
Titolo Testata:
CCC. Cancer causes & control
fascicolo: 3, volume: 7, anno: 1996,
pagine: 322 - 327
SICI:
0957-5243(1996)7:3<322:DOSFTD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARRETTS-ESOPHAGUS;
Keywords:
ESOPHAGEAL NEOPLASMS; SEER DATA; SURVIVAL; UNITED STATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Farrow e T.L. Vaughan, "DETERMINANTS OF SURVIVAL FOLLOWING THE DIAGNOSIS OF ESOPHAGEAL ADENOCARCINOMA (UNITED-STATES)", CCC. Cancer causes & control, 7(3), 1996, pp. 322-327

Abstract

The rapidly rising incidence of esophageal adenocarcinomas in the United States and western Europe remains unexplained. Most persons who develop the disease have had long-standing gastroesophageal reflux symptoms with concomitant Barrett's metaplasia. They are, therefore, potentially identifiable for endoscopic screening and cancer surveillance, which should facilitate the early detection of these tumors. We undertook these analyses to determine the extent to which the opportunity forearly diagnosis and treatment of esophageal adenocarcinomas has been realized in the US. Specifically, using data from the Surveillance, Epidemiology, and End Results (SEER) program of the US National Cancer Institute, we examined changes in stage of disease at diagnosis and in survival between 1973 and 1991 and investigated patient characteristics as predictors of survival. Improvements in stage at diagnosis and insurvival between 1973 and 1991 were minor and clinically insignificant; overall five-year survival never exceeded 10 percent. Stage of disease at diagnosis was the strongest determinant of subsequent survival;five-year survival with patients with in situ tumors was 68.2 percent. This survival advantage persisted up to 15 years after diagnosis andwas independent of other prognostic factors. We conclude that the opportunity for reduction in esophageal cancer mortality has been largelyunrealized in the US. In light of the increasing incidence of esophageal adenocarcinoma, efforts should be devoted to identifying those at highest risk of developing Barrett's metaplasia and subsequent adenocarcinoma, and to developing cost-effective primary prevention and cancer surveillance methods targetting them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:53:22