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Titolo:
PATHOGENIC MECHANISMS INDUCED BY MICROBIAL PROTEASES IN MICROBIAL INFECTIONS
Autore:
MAEDA H; YAMAMOTO T;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DEPT MICROBIOL KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DEPT MOLEC PATHOL KUMAMOTO 860 JAPAN
Titolo Testata:
Biological chemistry Hoppe-Seyler
fascicolo: 4, volume: 377, anno: 1996,
pagine: 217 - 226
SICI:
0177-3593(1996)377:4<217:PMIBMP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSEUDOMONAS-AERUGINOSA ELASTASE; EGG-WHITE OVOMACROGLOBULIN; PLASMA ALPHA-1-PROTEINASE INHIBITOR; VASCULAR-PERMEABILITY REACTION; KININ-GENERATING CASCADE; LATENT HUMAN NEUTROPHIL; HAGEMAN-FACTOR; PORPHYROMONAS-GINGIVALIS; SERRATIA-MARCESCENS; BACTERIAL PROTEASES;
Keywords:
BACTERIAL TRANSLOCATION; BACTERIAL PROTEASES; BRADYKININ; HAGEMAN FACTOR; PROTEASE INHIBITORS; SEPTICEMIA; SHOCK;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
97
Recensione:
Indirizzi per estratti:
Citazione:
H. Maeda e T. Yamamoto, "PATHOGENIC MECHANISMS INDUCED BY MICROBIAL PROTEASES IN MICROBIAL INFECTIONS", Biological chemistry Hoppe-Seyler, 377(4), 1996, pp. 217-226

Abstract

Most bacterial and fungal proteases excreted into infected hosts exhibit a wide range of pathogenic potentials ranging from pain, edema or even shock to translocation of bacteria from the site of infection into systemic circulation, thus resulting in septicemia, The basic mechanism or principle common to all these phenomena is explained by kinin generation, either directly from high- and/or low-molecular weight kininogens or indirectly via activation of the bradykinin generating cascade: i.e. Hageman factor It activated Hageman factor --> prekallikrein --> kallikrein --> high-molecular weight kininogen --> bradykinin. Some bacterial proteases are also involved in activation of other host protease zymogens such as plasminogen, procollagenase (matrix metallo proteases) and proenzymes of the clotting system, Furthermore, most bacterial proteases are not only resistant to plasma protease inhibitors of the hosts, most of which belong to a group of serine protease inhibitors called serpins (serine protease inhibitors), but they also quickly inactivate serpins. Some bacterial proteases may also activate bacterial toxins thus rendering toxigenic pathogenesis. They are also capable of degrading immunoglobulins and components of the complement system and facilitate propagation of micro organisms. All in all, microbialproteases are very critical in enhancing pathogenesis of severe diseases, It is also noteworthy that bacterial cell wall components themselves, i.e. endotoxin (or lipopolysaccharide) of gram negative bacteria and teichoic/lipoteichoic acid of gram positive bacteria, are also able to activate the bradykinin generating cascade - involving activationof Hageman factor as mentioned above.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:00:54