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Titolo:
BACTERIA AND BACTERIAL-CELL WALL CONSTITUENTS INDUCE THE PRODUCTION OF REGULATORY CYTOKINES IN DENDRITIC CELL CLONES
Autore:
RIVA S; NOLLI ML; LUTZ MB; CITTERIO S; GIROLOMONI G; WINZLER C; RICCIARDICASTAGNOLI P;
Indirizzi:
UNIV MILAN,CNR,CTR CYTOPHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,CNR,CTR CYTOPHARMACOL I-20129 MILAN ITALY MARION MERRELL DOW RES INST,LEPETIT RES CTR GERENZANO ITALY IST DERMOPATICO IMMACOLATA,IMMUNOL LAB ROME ITALY
Titolo Testata:
Journal of inflammation
fascicolo: 2, volume: 46, anno: 1996,
pagine: 98 - 105
SICI:
1078-7852(1996)46:2<98:BABWCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL LANGERHANS CELLS; TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; ANTIGEN-PRESENTING CELLS; LEISHMANIA-MAJOR; FACTOR-ALPHA; T-CELLS; IN-VIVO; SKIN; INTERLEUKIN-6;
Keywords:
DENDRITIC CELLS; ANTIGEN PRESENTING CELLS; MICROBIAL INFECTION; CELL ACTIVATION; CYTOKINE PRODUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S. Riva et al., "BACTERIA AND BACTERIAL-CELL WALL CONSTITUENTS INDUCE THE PRODUCTION OF REGULATORY CYTOKINES IN DENDRITIC CELL CLONES", Journal of inflammation, 46(2), 1996, pp. 98-105

Abstract

The primary function of dendritic cells (DC) is the uptake, processing, and presentation of antigens to unprimed T cells, but the regulation of these functions is largely unknown. The study of the signals thatmaintain DC in a resting state or that drive their activation has been hampered by the difficulties in obtaining pure DC populations. The availability of immortalized DC clones from differ ent tissues (spleen and skin) allowed us to investigate the regulation of cytokine production in response to physiological signals in the absence of contaminating cells. The DC clones exhibited the phenotypical and functional features of DC precursors and could phagocytose, albeit at a low rate, whole bacteria. Heat-inactivated bacteria and bacterial cell wall products were tested for cytokine induction. Lipopolysaccharide, lipoteichoicacid, and gram-negative bacteria were potent inducers of tumor necrosis factor or and interleukin 6 release, whereas gram-positive bacteriawere less efficient The results suggest that microbial infections candirectly promote cytokine DC release of relevant inflammatory responses as well as in the autocrine activation of DC. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:51:07