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Titolo:
USE OF MAMMALIAN LIVER-CELLS FOR ARTIFICIAL LIVER SUPPORT
Autore:
JAUREGUI HO; CHOWDHURY NR; CHOWDHURY JR;
Indirizzi:
BROWN UNIV,RHODE ISL HOSP,DEPT PATHOL & LAB MED,ALDRICH BLDG,ROOM 702,593 EDDY ST PROVIDENCE RI 02903 BROWN UNIV,RHODE ISL HOSP,DEPT PATHOL PROVIDENCE RI 02903 BROWN UNIV,DEPT PATHOL & LAB MED,DIV BIOL & MED PROVIDENCE RI 02906 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED & MOLEC GENET BRONX NY10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,MARION BESSIN LIVER RES CTR BRONX NY 10461
Titolo Testata:
Cell transplantation
fascicolo: 3, volume: 5, anno: 1996,
pagine: 353 - 367
SICI:
0963-6897(1996)5:3<353:UOMLFA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; HYBRID BIOARTIFICIAL LIVER; ADULT-RAT HEPATOCYTES; HEPATOCELLULAR TRANSPLANTATION; HEPATIC-FAILURE; MICROENCAPSULATED HEPATOCYTES; CARBAMOYLPHOSPHATE SYNTHETASE; ULTRAVIOLET-IRRADIATION; INTRATHYMIC INOCULATION; GLUTAMINE-SYNTHETASE;
Keywords:
LIVER ASSIST DEVICE; HEPATOCYTE TRANSPLANTATION; HOLLOW FIBERS; BIOARTIFICIAL LIVER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
134
Recensione:
Indirizzi per estratti:
Citazione:
H.O. Jauregui et al., "USE OF MAMMALIAN LIVER-CELLS FOR ARTIFICIAL LIVER SUPPORT", Cell transplantation, 5(3), 1996, pp. 353-367

Abstract

Advances in orthotopic liver transplantation have improved the survival rate of both acute and chronic liver failure patients to nearly 70%. However, the success of this treatment modality has created an international organ shortage, Many patients die while awaiting transplantation in part due to the minimal capacity to store viable transplantablelivers beyond 24 h, Additionally, for many areas of the world, routine use of whole liver transplantation to treat liver disease is impractical due to the demands on both financial and technical resources, Potentially, these issues may be alleviated, at least in part, by the useof liver cell transplantation or cellular-based liver assist devices,The well-documented regenerative capacity of the liver may obviate the need for whole organ transplantation in some instances of acute failure, if the patient may be provided temporary metabolic support. Although other patients ultimately may require transplantation, a longer period of time to find a suitable organ for transplantation may be gained by that supportive therapy, The field of liver cell transplantation may offer solutions to patients with inherited metabolic deficiencies or chronic liver disease. The potential to treat an hepatic disorder by using only a fraction of the whole liver would increase the number of whole organs available for orthotopic liver transplantation. Research in the fields of hepatocyte based intra- and extracorporeal Liver support is providing evidence that these therapeutic modalities may ultimately become routine in the treatment of severe liver disease. A historic overview of that technology along with its current status is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 15:19:43