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Titolo:
PREDICTION OF THE SECONDARY STRUCTURE OF HIV-1 GP120
Autore:
HANSEN JE; LUND O; NIELSEN JO; BRUNAK S; HANSEN JES;
Indirizzi:
TECH UNIV DENMARK,CTR BIOL SEQUENCE ANAL,BLDG 206 DK-2800 LYNGBY DENMARK TECH UNIV DENMARK,CTR BIOL SEQUENCE ANAL DK-2800 LYNGBY DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB DK-2650 COPENHAGEN DENMARK TECH UNIV DENMARK,DEPT PHYS DK-2800 LYNGBY DENMARK
Titolo Testata:
Proteins
fascicolo: 1, volume: 25, anno: 1996,
pagine: 1 - 11
SICI:
0887-3585(1996)25:1<1:POTSSO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PRINCIPAL NEUTRALIZING DETERMINANT; ENVELOPE GLYCOPROTEIN GP120; CD4 BINDING-SITE; TYPE-1 GP120; RECEPTOR-BINDING; V3 LOOP; MONOCLONAL-ANTIBODIES; CONFORMATIONAL SWITCH; SURFACE GLYCOPROTEIN;
Keywords:
HIV-1 GP120; SECONDARY STRUCTURE; PREDICTION; MULTIPLE ALIGNMENT; CD4-BINDING SITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Hansen et al., "PREDICTION OF THE SECONDARY STRUCTURE OF HIV-1 GP120", Proteins, 25(1), 1996, pp. 1-11

Abstract

The secondary structure of HIV-1 gp120 was predicted using multiple alignment and a combination of two independent methods based on neural network and nearest-neighbor algorithms. The methods agreed on the secondary structure for 80% of the residues in BH10 gp120. Six helices were predicted in HIV strain BH10 gp120, as well as in 27 other HIV-1 strains examined, Two helical segments were predicted in regions displaying profound sequence variation, one in a region suggested to be critical for CD4 binding. The predicted content of helix, beta-strand, and coil was consistent with estimates from Fourier transform infrared spectroscopy. The predicted secondary structure of gp120 compared well with data from NMR analysis of synthetic peptides from the V3 loop and the C4 region. As a first step towards modeling the tertiary structure of gp120, the predicted secondary structure may guide the design of future HIV subunit vaccine candidates. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:52:03