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Titolo:
KAINIC ACID ACTIVATES TRANSIENT EXPRESSION OF TENASCIN-C IN THE ADULT-RAT HIPPOCAMPUS
Autore:
NAKIC M; MITROVIC N; SPERK G; SCHACHNER M;
Indirizzi:
SWISS FED INST TECHNOL,DEPT NEUROBIOL,HONGGERBERG CH-8093 ZURICH SWITZERLAND SWISS FED INST TECHNOL,DEPT NEUROBIOL CH-8093 ZURICH SWITZERLAND INNSBRUCK UNIV,DEPT PHARMACOL A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
Journal of neuroscience research
fascicolo: 4, volume: 44, anno: 1996,
pagine: 355 - 362
SICI:
0360-4012(1996)44:4<355:KAATEO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURITE OUTGROWTH; MESSENGER-RNA; SYNAPTIC REORGANIZATION; ENHANCED EXPRESSION; CYTOTACTIN; SEIZURES; MOUSE; MOLECULE; GROWTH; NERVE;
Keywords:
EXTRACELLULAR MATRIX; NEURONAL REGENERATION; RECOGNITION MOLECULE; SEIZURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakic et al., "KAINIC ACID ACTIVATES TRANSIENT EXPRESSION OF TENASCIN-C IN THE ADULT-RAT HIPPOCAMPUS", Journal of neuroscience research, 44(4), 1996, pp. 355-362

Abstract

Kainic acid-induced limbic seizures enhance expression of tenascin-C (TN) in the hippocampus of adult rats, TN mRNA was detectable by in situ hybridization in many granule cells in the dentate gyrus 4.5 hr after kainic acid injection but not in saline-injected animals (controls)or in animals killed 2 or 24 hr after injection, Thirty days after kainic acid injection, TN mRNA was detectable only in pyramidal cells ofCA3 and CA1. At the protein level, TN was detectable by immunocytochemistry in control animals in the strata oriens and lacunosum moleculare of CA1, in the molecular layer, and within a narrow area at the inner surface of the granule cell layer in the dentate gyrus. Twenty-four hours after kainic acid injection, TN immunoreactivity was enhanced inthese areas and throughout the granule cell layer, Thirty days after kainic acid injection, TN immunoreactivity was downregulated in these areas, while it was prominent in the stratum oriens and in clusters ofimmunoreactivity in the stratum lucidum of CA3, Western blot analysisof the hippocampus showed a peak of TN expression 24 hr after kainic acid injection, These observations show that TN expression is upregulated in predominantly neuronal cells already by 4.5 hr after kainic acid injection, coincident with activation of granule cells and sproutingof axon terminals, whereas the remaining TN expression 30 days after injection relates to pyramidal cells in CA1 and CA3, coincident with an astroglial response, as marked by a strong expression of glial fibrillary acidic protein. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:13:10