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Titolo:
NEUROFILAMENT PHOSPHORYLATION IS MODULATED BY MYELINATION
Autore:
STARR R; ATTEMA B; DEVRIES GH; MONTEIRO MJ;
Indirizzi:
UNIV MARYLAND,CTR MED BIOTECHNOL,INST BIOTECHNOL,SCH MED,ROOM 12-044 BRESSLER RES BLDG BALTIMORE MD 21201 UNIV MARYLAND,CTR MED BIOTECHNOL,INST BIOTECHNOL,SCH MED BALTIMORE MD21201 UNIV MARYLAND,SCH MED,DEPT NEUROL BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,DIV HUMAN GENET BALTIMORE MD 21201 LOYOLA UNIV,DEPT CELL BIOL & ANAT HINES IL 00000
Titolo Testata:
Journal of neuroscience research
fascicolo: 4, volume: 44, anno: 1996,
pagine: 328 - 337
SICI:
0360-4012(1996)44:4<328:NPIMBM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROOT GANGLION NEURONS; MONOCLONAL-ANTIBODIES DISTINGUISH; HEREDITARY HYPOTROPHIC AXONOPATHY; SCHWANN-CELLS; AXONAL-TRANSPORT; NERVOUS-SYSTEM; SCIATIC-NERVE; NF-H; SUBUNITS; CALIBER;
Keywords:
KINASES; NEURONS; GLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R. Starr et al., "NEUROFILAMENT PHOSPHORYLATION IS MODULATED BY MYELINATION", Journal of neuroscience research, 44(4), 1996, pp. 328-337

Abstract

Axons undergo substantial changes in radial growth during the course of development, Recent evidence suggests that axonal diameter may be controlled by the state of neurofilament (NF) phosphorylation. Using dorsal root ganglion (DRG)Schwann cell co-cultures, we provide direct evidence that phosphorylation of NF is regulated by myelination, NF phosphorylation increased upon myelination of DRG neurons by Schwann cells. The increase in NF phosphorylation was reflected both as an increasein immunoreactivity with the antibody SMI31, specific for phosphorylation-dependent NF epitopes, and a concomitant decrease in immunoreactivity with SMI32, specific for nonphosphorylated NF epitopes, The increase in NF phosphorylation induced by myelination in the neuron-glia co-cultures was similar to NF phosphorylation seen in sciatic nerve extracts of mice with normal myelination compared to Trembler J mouse littermates in which myelination of peripheral nerves is compromised, Using an in situ gel kinase assay, we have detected changes in individual NF kinase activities during myelination. In particular, a 35-kDa kinase activity was induced by myelination, whereas a 42-kDa kinase decreased in activity, We discuss the possibility that these and other kinases may be involved in signaling processes between neurons and glia during myelination. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:18:16