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Titolo:
INFLAMMATORY PSEUDOTUMOR OF THE LIVER - EVIDENCE FOR FOLLICULAR DENDRITIC RETICULUM-CELL PROLIFERATION-ASSOCIATED WITH CLONAL EPSTEIN-BARR-VIRUS
Autore:
SELVES J; MEGGETTO F; BROUSSET P; VOIGT JJ; PRADERE B; GRASSET D; ICART J; MARIAME B; KNECHT H; DELSOL G;
Indirizzi:
CHU PURPAN,ANAT PATHOL LAB,PL DR BAYLAC F-31059 TOULOUSE FRANCE CHU PURPAN,ANAT PATHOL LAB F-31059 TOULOUSE FRANCE CHU PURPAN,CIGH,CNRS F-31059 TOULOUSE FRANCE CHU PURPAN,DEPT GEN SURG F-31059 TOULOUSE FRANCE CHU RANGUEIL,VIROL LAB F-31054 TOULOUSE FRANCE GEN HOSP,DEPT INTERNAL MED MONTAUBAN FRANCE UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV HEMATOL ONCOL WORCESTER MA 00000
Titolo Testata:
The American journal of surgical pathology
fascicolo: 6, volume: 20, anno: 1996,
pagine: 747 - 753
SICI:
0147-5185(1996)20:6<747:IPOTL->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
REED-STERNBERG CELLS; LATENT MEMBRANE-PROTEIN; HODGKINS-DISEASE; NASOPHARYNGEAL CARCINOMA; INSITU HYBRIDIZATION; LYMPH-NODES; EXPRESSION; PROBES; EBV; SPLEEN;
Keywords:
LIVER; EPSTEIN-BARR VIRUS; INFLAMMATORY PSEUDOTUMOR; FOLLICULAR DENDRITIC RETICULUM CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Selves et al., "INFLAMMATORY PSEUDOTUMOR OF THE LIVER - EVIDENCE FOR FOLLICULAR DENDRITIC RETICULUM-CELL PROLIFERATION-ASSOCIATED WITH CLONAL EPSTEIN-BARR-VIRUS", The American journal of surgical pathology, 20(6), 1996, pp. 747-753

Abstract

We describe an ''inflammatory pseudotumor'' of the liver that, which on detailed investigation, proved that the spindle-cell component of this lesion is derived from follicular dendritic reticulum cells (FDRC). This contention is supported by morphologic observations and by immunophenotype. The FDRC population contained Epstein-Barr virus (EBV). It is known that FDRC express the EBV receptor CD21. In this particularcase, the FDRC contained clonal EBV genomes, EBV RNA (EBER) transcripts, and expressed EBV latent membrane protein (LMP1). DNA sequencing of PCR products showed three point mutations compared with the standardLMP1 sequence of the EBV strain B95-8. The findings in this case corroborate those of other investigators concerning the possible role of EBV in the development of some inflammatory pseudotumors, including therecent production of functionally active EBV-transformed FDRC-like cell lines. This association could prove instructive in delineating the histogenesis of these tumors and further assist in making prognostic and therapeutic decisions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:22:44