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Titolo:
EFFECTIVENESS AND SAFETY OF ONCE-DAILY AMINOGLYCOSIDES - A METAANALYSIS
Autore:
FERRIOLSLISART R; ALOSALMINANA M;
Indirizzi:
HOSP GEN CASTELLON,SERV PHARM,AVE BENICASIM S-N E-12004 CASTELLO DE PLANA SPAIN UNIV VALENCIA E-46100 VALENCIA SPAIN
Titolo Testata:
American journal of health-system pharmacy
fascicolo: 10, volume: 53, anno: 1996,
pagine: 1141 - 1150
SICI:
1079-2082(1996)53:10<1141:EASOOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAM-NEGATIVE INFECTIONS; FEBRILE NEUTROPENIC PATIENTS; NETILMICIN PLUS CEFTRIAXONE; URINARY-TRACT INFECTIONS; DAILY DOSE AMIKACIN; PEDIATRIC-PATIENTS; COMPARATIVE TRIAL; A-DAY; GRANULOCYTOPENIC PATIENTS; PSEUDOMONAS-AERUGINOSA;
Keywords:
AMINOGLYCOSIDES; CLINICAL STUDIES; DOSAGE SCHEDULES; DRUGS, CLINICAL EFFECTIVENESS; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
103
Recensione:
Indirizzi per estratti:
Citazione:
R. Ferriolslisart e M. Alosalminana, "EFFECTIVENESS AND SAFETY OF ONCE-DAILY AMINOGLYCOSIDES - A METAANALYSIS", American journal of health-system pharmacy, 53(10), 1996, pp. 1141-1150

Abstract

The effectiveness and safety of once-daily versus several-times-dailyaminoglycosides were studied in a meta-analysis. MEDLINE for 1988 to 1995 was searched, and additional studies were identified from review articles and references in retrieved articles. Studies selected for meta-analysis were randomized controlled clinical trials in nonneutropenic adult patients comparing the clinical effectiveness or nephrotoxicity or ototoxicity of once-daily with several-times-daily aminoglycosides. Differences between groups The results were combined by were expressed as odds ratios. the procedure of Mantel and Haenszel, and 95% confidence intervals and exact confidence intervals were computed. An odds ratio smaller than 1 would indicate a lesser likelihood of a given endpoint in the once-daily group, and an odds ratio greater than 1 would indicate a greater likelihood. Eighteen studies involving 2317 patients were included in the meta-analysis. Summary odds ratios were 1.47 for effectiveness (95% CI = 1.13-1.94), 0.56 for ototoxicity (95% CI =0.26-1.16), and 0.60 for nephrotoxicity (95% CI = 0.40-0.86) A meta-analysis showed that treatment with single daily doses of aminoglycosides seems to be more effeclive, less nephrotoxic, and as ototoxic as multiple doses daily.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:45:11