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Titolo:
RADIOSENSITIZATION IN NORMAL-TISSUES WITH OXYGEN, CARBOGEN OR NICOTINAMIDE - THERAPEUTIC GAIN COMPARISONS FOR FRACTIONATED X-RAY SCHEDULES
Autore:
ROJAS A; VOJNOVIC B; JOHNS H; JOINER MC; MARTINDALE C; FOWLER JF; DENEKAMP J;
Indirizzi:
MT VERNON HOSP,CANC RES TRUST,GRAY LAB,POB 100 NORTHWOOD HA6 2JR MIDDX ENGLAND UMEA UNIV HOSP,DEPT ONCOL S-90185 UMEA SWEDEN
Titolo Testata:
Radiotherapy and oncology
fascicolo: 1, volume: 39, anno: 1996,
pagine: 53 - 64
SICI:
0167-8140(1996)39:1<53:RINWOC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE MAMMARY-CARCINOMA; NORMOBARIC OXYGEN; HYPERBARIC-OXYGEN; TUMOR RADIOSENSITIVITY; RADIATION RESPONSE; MURINE SARCOMA; RENAL DAMAGE; NECK-CANCER; SKIN; IRRADIATION;
Keywords:
OXYGEN; CARBOGEN; NICOTINAMIDE; ARCON; SKIN; LUNG; GUT; KIDNEY; FRACTIONATION; THERAPEUTIC BENEFIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
A. Rojas et al., "RADIOSENSITIZATION IN NORMAL-TISSUES WITH OXYGEN, CARBOGEN OR NICOTINAMIDE - THERAPEUTIC GAIN COMPARISONS FOR FRACTIONATED X-RAY SCHEDULES", Radiotherapy and oncology, 39(1), 1996, pp. 53-64

Abstract

Methods: Radiosensitisation with oxygen, carbogen or nicotinamide alone and oxygen or carbogen combined with nicotinamide was compared in early and late responding normal tissues in rodents. X-ray treatments were delivered as single doses or fractionated schedules of 2 fractionsin 1 day, 2, 12 and 36 fractions in an overall time of 12 days and 10fractions in 5 or 12 days. Acute skin reactions, survival of intestinal crypts, breathing rate, reduction in the packed red-cell volume andclearance of Cr-51-EDTA were used as assays of epidermal, gut, lung and renal damage. Results: Relative to air-breathing mice, carbogen or oxygen produced a small, and not always significant, increase in sensitivity (enhancement ratios less than or equal to 1.15) in gut, lung and kidneys; however, in skin a dose enhancement of 1.2-1.3 was observed. The effect of nicotinamide in air, carbogen or oxygen was studied only in lung and gut. The drug produced variable but generally significant increases in radiosensitisation (less than or equal to 1.26) in allthree gases. Relative to treatments in air, enhancement ratios for nicotinamide alone were usually slightly higher than those observed wheneither carbogen or oxygen were administered without the drug. With all three modifiers (i.e. oxygen, carbogen, nicotinamide alone or for the drug-gas combinations) there was no significant change in the enhancement ratios observed as the number of radiation dose fractions was varied. Conclusions: Comparisons with fractionated X-ray studies done previously in rodent tumours indicate that a therapeutic benefit, relative to lung, gut and renal damage, would be observed with oxygen or carbogen alone but not with nicotinamide alone. The greatest gain would be achieved with the combination of carbogen and nicotinamide, with which a benefit was observed even relative to epidermal damage. These results indicate that some decrease in normal tissue tolerance could be observed when using these modifiers in clinical radiotherapy and, although small, the appropriate dose reductions should be considered; caution should be exercised especially when carbogen and nicotinamide are used in conjunction with the more radical accelerated schedules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:43:58