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Titolo:
EFFECTS OF STEROIDS ON THE LUNG ACCUMULATION OF NEUTROPHIL AND MONOCYTE IN RABBITS WITH ENDOTOXEMIA
Autore:
NAKAGAWA M; OHGAMI M; ANDO N; WAKABAYASHI G; KITAJIMA M;
Indirizzi:
KAWASAKI CITY HOSP,DEPT SURG,KAWASAKI KU,12-1 SHINKAWADORI KAWASAKI KANAGAWA 210 JAPAN KEIO UNIV,SCH MED,DEPT SURG TOKYO 160 JAPAN
Titolo Testata:
Chest
fascicolo: 5, volume: 109, anno: 1996,
pagine: 1339 - 1345
SICI:
0012-3692(1996)109:5<1339:EOSOTL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RESPIRATORY-DISTRESS SYNDROME; SEPTIC SHOCK; VASCULAR-PERMEABILITY; ADHESION MOLECULE-1; GENE-EXPRESSION; PULMONARY-EDEMA; FACTOR-ALPHA; INJURY; SEPSIS;
Keywords:
ENDOTOXEMIA; LEUKOCYTE; LUNG ACCUMULATION; METHYLPREDNISOLONE; MONOCYTE; NEUTROPHIL; TUMOR NECROSIS FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakagawa et al., "EFFECTS OF STEROIDS ON THE LUNG ACCUMULATION OF NEUTROPHIL AND MONOCYTE IN RABBITS WITH ENDOTOXEMIA", Chest, 109(5), 1996, pp. 1339-1345

Abstract

Study objective: To determine the effects of steroids on the lung accumulation of polymorphonuclear leukocytes (PMNs) and monocytes in rabbits with endotoxemia. Design: A prospective, randomized, controlled animal trial. Setting: Surgical research laboratory, Keio University School of Medicine. Subjects: Twenty-four female Japanese white rabbits, Interventions: Rabbits with endotoxemia were pretreated with steroids sufficient to inhibit the production of tumor necrosis factor (TNF) and to prevent the fall of BP. Measurements and results: The circulatingleukocyte counts and the leukocyte accumulation in the lung were evaluated. Endotoxin caused a rapid decrease in circulating PMNs and monocytes followed by an 8-fold greater accumulation of PMNs (p<0.001) and a 6.5-fold greater accumulation of monocytes (p<0.05). Steroids failedto inhibit this initial drop of PMNs and monocytes. However, steroidsinhibited the PMN accumulation in the lung by 50% (p<0.05), without inhibiting the monocyte accumulation in the lung. Conclusions: These findings suggest that the lung accumulation of PMNs is dependent on TNF or other inflammatory mediators that are inhibited by steroids while the lung accumulation of monocyte is not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 08:31:10