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Titolo:
VOLEMIC STATUS INFLUENCES THE RESPONSE OF PLASMA ATRIAL-NATRIURETIC-FACTOR TO POSITIVE AIRWAY PRESSURE
Autore:
BEURET P; FEIHL F; NUSSBERGER J; BRUNNER HR; PERRET C;
Indirizzi:
CHU VAUDOIS,INST PATHOPHYSIOL,BH-19 CH-104 LAUSANNE SWITZERLAND CHU VAUDOIS,DIV HYPERTENS CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,INST PHYSIOPATHOL CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
Chest
fascicolo: 5, volume: 109, anno: 1996,
pagine: 1313 - 1319
SICI:
0012-3692(1996)109:5<1313:VSITRO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
END-EXPIRATORY PRESSURE; LEFT-VENTRICULAR FUNCTION; VOLUME-EXPANDED DOGS; MECHANICAL VENTILATION; PEEP VENTILATION; RENAL-FUNCTION; PEPTIDE RELEASE; ANTIDIURETIC-HORMONE; PERICARDIAL PRESSURE; HUMANS;
Keywords:
ATRIAL NATRIURETIC FACTOR; POSITIVE PRESSURE RESPIRATION; RESPIRATION, ARTIFICIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Beuret et al., "VOLEMIC STATUS INFLUENCES THE RESPONSE OF PLASMA ATRIAL-NATRIURETIC-FACTOR TO POSITIVE AIRWAY PRESSURE", Chest, 109(5), 1996, pp. 1313-1319

Abstract

Study objective: To evaluate interactive effects of volemic status and positive end-expiratory pressure (PEEP) on tile plasma levels or atrial natriuretic factor (ANF) in assist-controlled mechanical ventilation (MV). Design: Three successive protocols applied in randomized order to each participant. Setting: Clinical investigation laboratory. Participants: Twenty-one young, healthy adults. Interventions: The three protocols were as follows: (1) MV+PEEP, normovolemia; (2) MV+PEEP, hypervolemia; and (3) spontaneous breathing (SE), hypervolemia. In protocols 1 and 2, a preliminary period of SE lasting 2 h was followed by MValone (0.5 h), MV+20 cm H2O PEEP (1 h), and a recovery period of SE (1.5 h). Hypervolemia was induced by the continuous IV infusion of 3 L of 0.9% NaCl in 5 h (protocols 2 and 3). Measurements and results: Heart rate, BP, and the plasma levels of immunoreactive ANF and catecholamines were measured serially, During hypervolemia, ANF significantly decreased when PEEP was added to MV (protocol 2: from 31.1+/-2.7 to 20.7+/-1.5 fmol/mL; p<0.01). This did not occur in normovolemia (protocol1: from 20.0+/-2.0 to 16.7+/-1.2 fmol/mL; p=NS). The different effects of MV+PEEP in normovolemia and hypervolemia were not related to differences in circulating catecholamine levels. Conclusions: These results demonstrate for the first time (to our knowledge) that volemic status modulates the response of plasma ANF to PEEP in humans. Tire role ofANF in the water and salt retention induced by MV with PEEP might be limited to hypervolemic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:17:17