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Titolo:
CHANGES IN DNA INDUCED BY TOXIC AGENTS
Autore:
SAWAGUCHI T; WANG XL; SAWAGUCHI A;
Indirizzi:
TOKYO WOMENS MED COLL,DEPT LEGAL MED,SHINJUKU KU,8-1 KAWADA CHO TOKYO162 JAPAN
Titolo Testata:
Forensic science international
fascicolo: 3, volume: 78, anno: 1996,
pagine: 169 - 178
SICI:
0379-0738(1996)78:3<169:CIDIBT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; TETRANUCLEOTIDE REPEAT POLYMORPHISM; ENZYMATIC AMPLIFICATION; TELOMERE REDUCTION; VARIABLE NUMBER; MINISATELLITE; LOCUS; GENE; FINGERPRINT; CLONING;
Keywords:
DNA CHANGE; CO; METHAMPHETAMINE; DNA FINGERPRINTING; HLADQ-ALPHA; AMPFLP; D1S80; TH01; TPOX; CSF1PO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T. Sawaguchi et al., "CHANGES IN DNA INDUCED BY TOXIC AGENTS", Forensic science international, 78(3), 1996, pp. 169-178

Abstract

This is a preliminary report on significant alterations in the DNA profile caused by toxic substances which potentially has profound implications for the use of DNA techniques in identification. Acute DNA changes in the globus pallidus of the brain in man caused by carbon monoxide poisoning were detected by DNA profiling with probe 33.15. Chronic DNA changes in rabbits caused by methamphetamine were detected by DNA profiling with probe 33.15, AmpFLP on D1S80, TH01, CSF1PO and TPOX loci. Pre-intoxication bands appeared, disappeared or were discoloured after intoxication. With PCR-dot blot hybridization testing for HLADQ alpha, pre-intoxication positive spots became negative after intoxication and pre-intoxication negative spots became positive after intoxication. Intravenous injection of 10 mg/kg of methamphetamine every 2 days for 2 weeks was a large enough dose for inducement of genetic changes. In this investigation, clear changes in DNA due to intoxication were confirmed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:35:40